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| 005 | 20231030041518.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\24147 | ||
| 090 | _a657603 | ||
| 100 | _a20180220a2018 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aIN | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aLithium ascorbate as a protector of human blood biomolecules under ethanol impact _fE. V. Plotnikov [et al.] |
|
| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: p. 85-86 (35 tit.)] | ||
| 330 | _aBackground: Alcoholism is an acute social problem worldwide for negative impact on health. This problem is closelyassociated with social stress and drinking traditions. Previously, it was established exhaustion of blood antioxidant inalcoholism patients. It requires development and investigation of substances with protective properties under ethanol impact,on both cells and biomolecules. Aims and Objectives: Lithium salts are widely used in medicine as mood stabilizers formental pathologies, including alcoholism. In this work, we investigate lithium ascorbate for the protection of humanblood plasma lipids and proteins under ethanol impact. Materials and Methods: Well-known antioxidants - carnosineand ascorbic acid - were used as reference drugs. Heparinized venous blood was used as an experimental substrate. Theethanol and tested substances in the form of water (physiological)solutions were added to blood in vitro. Protection effectswere measured and estimated as concentrations of carbonyls proteins and products of lipid peroxidation in blood plasma.Results: It was shown similar protective action of lithium ascorbate and carnosine on human plasma biomolecules againstdamaging action of ethanol. No protective effect revealed for ascorbic acid. Conclusion: Lithium ascorbate and carnosinewere proved to possess the protection effects for blood lipids and proteins under ethanol impact. Normothymic and bloodprotectiveproperties are desirable for psychotropic drugs, and thus, lithium salts could be considered as prospective agentsin the treatment of addictions and other pathologies associated with oxidative stress. | ||
| 461 | _tNational Journal of Physiology, Pharmacy and Pharmacology | ||
| 463 |
_tVol. 8, iss. 1 _v[P. 82-86] _d2018 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aаскорбаты | |
| 610 | 1 | _aлитий | |
| 610 | 1 | _aэтанол | |
| 610 | 1 | _aкарбонилы | |
| 610 | 1 | _aалкоголизм | |
| 701 | 1 |
_aPlotnikov _bE. V. _cchemist _cEngineer of Tomsk Polytechnic University _f1983- _gEvgeny Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\32469 |
|
| 701 | 1 |
_aProkopjeva _bV. D. _gValentina Danilovna |
|
| 701 | 1 |
_aYarygina _bE. E. _gEkaterina Ekaterina |
|
| 701 | 1 |
_aLosenkov _bI. S. _gInnokenty Sergeevich |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20180220 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.5455/njppp.2018.8.0935812102017 | |
| 942 | _cCF | ||