| 000 | 02936nlm1a2200409 4500 | ||
|---|---|---|---|
| 001 | 657605 | ||
| 005 | 20231030041518.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\24149 | ||
| 090 | _a657605 | ||
| 100 | _a20180220a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aNL | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aQuantitative determination of new anti-inflammatory drug indomenthyl and its metabolite in rabbit plasma by HPLC-MS/MS _fK. A. Leonov, A. V. Bykova, V. V. Bykov [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 24 tit.] | ||
| 330 | _aBackground: Indomenthyl is an innovative anti-inflammatory drug with a high analgesic activity. Indomenthyl releases indomethacin under the influence of neutrophil esterases in the inflammation focus. Methodology/results: This research is aimed at developing a highly sensitive method for the quantitative determination of indomenthyl and its active metabolite indomethacin in rabbit plasma by HPLC-MS/MS. Protein precipitation and extraction with acetonitrile were used for analyte isolation from plasma according to the QuEChERS principle. The target quantitative ion pairs m/z were respectively 496.4 / 358.0 for indomenthyl, 358.0 / 139.5 for indomethacin, and 340.1 / 202.1 for the IS. Conclusion: The calibration curve was linear over the range 0.1-1000 ng mL1 . The technique was applied to the pharmacokinetic study at a dose of 25 mg kg1 to rabbits | ||
| 461 | _tAnalytical Methods | ||
| 463 |
_tVol. 13, iss. 41 _v[9 p.] _d2021 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aLeonov _bK. A. _gKlim Andreevich |
|
| 701 | 1 |
_aBykova _bA. V. _gArina Vladimirovna |
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| 701 | 1 |
_aBykov _bV. V. _gVladimir Valerjevich |
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| 701 | 1 |
_aVishenkova _bD. A. _cchemist _cengineer of Tomsk Polytechnic University _f1989- _gDariya Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33918 |
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| 701 | 1 |
_aLipskikh _bO. I. _cchemist _cengineer of Tomsk Polytechnic University _f1984- _gOlga Ivanovna _2stltpush _3(RuTPU)RU\TPU\pers\38489 |
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| 701 | 1 |
_aDorozhko _bE. V. _cchemist _cEngineer of Tomsk Polytechnic University _f1979- _gElena Vladimirovna _2stltpush _3(RuTPU)RU\TPU\pers\32174 |
|
| 701 | 1 |
_aPavlovsky _bV. I. _cchemist _cProfessor of Tomsk Polytechnic University, Doctor of chemical sciences _f1958- _gViktor Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\46884 |
|
| 701 | 1 |
_aVengerovsky _bA. I. _gAleksandr Isaakovich |
|
| 701 | 1 |
_aUdut _bV. V. _gVladimir Vasiljevich |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа природных ресурсов _bОтделение химической инженерии _h8085 _2stltpush _3(RuTPU)RU\TPU\col\23513 |
| 801 | 2 |
_aRU _b63413507 _c20221024 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1039/D1AY01220G | |
| 942 | _cCF | ||