| 000 | 05735nla2a2200553 4500 | ||
|---|---|---|---|
| 001 | 657734 | ||
| 005 | 20231030041523.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\24460 | ||
| 035 | _aRU\TPU\network\24458 | ||
| 090 | _a657734 | ||
| 100 | _a20180314a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 105 | _ay z 100zy | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aThe Foundations of the Development of Technologies of the Synthesis of Radiopharmaceuticals _fM. Larkina, E. V. Podrezova, O. Bragina [et al.] |
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| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 15 tit.] | ||
| 330 | _aThe selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodoaliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 0 |
_0(RuTPU)RU\TPU\network\4816 _tAIP Conference Proceedings |
|
| 463 | 0 |
_0(RuTPU)RU\TPU\network\24427 _tVol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17) _oProceedings of the International conference, 23–26 May 2017, Tomsk, Russia _fNational Research Tomsk Polytechnic University (TPU) ; eds. E. Y. Gutmanas, O. B. Naimark, Yu. P. Sharkeev _v[020043, 3 p.] _d2017 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aсинтез | |
| 610 | 1 | _aрадиофармпрепараты | |
| 610 | 1 | _aмишени | |
| 610 | 1 | _aядерная медицина | |
| 610 | 1 | _aрадионуклиды | |
| 610 | 1 | _aтерапия | |
| 701 | 1 |
_aLarkina _bM. S. _cpharmacist _cResearcher of the Tomsk Polytechnic University, Candidate of Pharmaceutical Sciences _f1984- _gMariya Sergeevna _2stltpush _3(RuTPU)RU\TPU\pers\46781 |
|
| 701 | 1 |
_aPodrezova _bE. V. _cChemist _cEngineer of Tomsk Polytechnic University _f1992- _gEkaterina Vladimirovna _2stltpush _3(RuTPU)RU\TPU\pers\40301 |
|
| 701 | 1 |
_aBragina _bO. D. _cspecialist in the field of medical technology _cAssociate Scientist of Tomsk Polytechnic University, Candidate of medical Sciences _f1986- _gOlga Dmitrievna _2stltpush _3(RuTPU)RU\TPU\pers\35943 |
|
| 701 | 1 |
_aStasyuk _bE. S. _cSpecialist in the field of nuclear power engineering _cResearcher of Tomsk Polytechnic University, Candidate of technical sciences _f1978- _gElena Sergeyevna _2stltpush _3(RuTPU)RU\TPU\pers\32656 |
|
| 701 | 1 |
_aYusubov _bM. S. _cchemist _cProfessor of Tomsk Polytechnic University, Doctor of chemical sciences _f1961- _gMekhman Suleiman-Ogly (Suleimanovich) _2stltpush _3(RuTPU)RU\TPU\pers\31833 |
|
| 701 | 1 |
_aChernov _bV. I. _cspecialist in the field of medical technology _clead engineer of Tomsk Polytechnic University, doctor of medical sciences _f1962- _gVladimir Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\34191 |
|
| 701 | 1 |
_aZelchan _bR. V. _cspecialist in the field of medical technology _claboratory Tomsk Polytechnic University _f1984- _gRoman Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\34194 |
|
| 701 | 1 |
_aSkuridin _bV. S. _cPhysicist, Specialist in the field of nuclear power engineering _cProfessor of Tomsk Polytechnic University, Doctor of technical sciences _f1946- _gViktor Sergeyevich _2stltpush _3(RuTPU)RU\TPU\pers\32655 |
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| 701 | 1 |
_aBelousov _bM. |
|
| 701 | 1 |
_aDeev _bS. M. _cbiologist _cthe expert of Tomsk Polytechnic University, doctor of biological Sciences _gSergey Mikhaylovich _2stltpush _3(RuTPU)RU\TPU\pers\39299 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут природных ресурсов (ИПР) _bКафедра технологии органических веществ и полимерных материалов (ТОВПМ) _h6832 _2stltpush _3(RuTPU)RU\TPU\col\18659 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bЛаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР) _h6471 _2stltpush _3(RuTPU)RU\TPU\col\20054 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20210302 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1063/1.5001622 | |
| 856 | 4 | _uhttp://earchive.tpu.ru/handle/11683/46882 | |
| 942 | _cCF | ||