| 000 | 05117nla2a2200505 4500 | ||
|---|---|---|---|
| 001 | 657745 | ||
| 005 | 20231030041524.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\24471 | ||
| 035 | _aRU\TPU\network\24469 | ||
| 090 | _a657745 | ||
| 100 | _a20180314a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 105 | _ay z 100zy | ||
| 135 | _adrgn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aNuclear Medicine in Breast Cancer Diagnostics: Primary Tumor and Lymphatic Metastasis _fI. G. Sinilkin, А. А. Medvedeva, V. I. Chernov [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 24 tit.] | ||
| 330 | _aThe purpose of the study: to assess the possibility of using nuclear medicine techniques at the stages of diagnosis and treatment of breast cancer. Materials and Methods: The study included 290 patients with breast cancer and 70 patients with benign breast tumors. The study was used as a radiopharmaceutical 99mTc-MIBI, 199Tl for imaging tumors and colloid 99mTc-Aloteh for visualization sentinel lymph nodes (SLN), colloid was injected peritumoral in four points to 80 MBq one day prior to the planned operation. Results: The sensitivity of SPECT using both 99mTc-MIBI and 199Tl for breast cancer detection was shown to be rather high, being 98.5% and 98%, respectively. It should be noted that the sensitivity of SPECT in detection of small tumors (less than 1 cm in diameter) and multicentric tumors was not high irrespective of the radioisotope used (60% and 65% with 99mTc-MIBI and 65% and 59% with 199Tl, respectively). The difference in the sensitivity was found between 99mTc-MIBI and 199T for the detection of regional lymph node metastasis (91% vs 70%). SLN were detected in 31 patients. The most commonly SLN were defined in the axillary region of 96.7%. In 22 (70.9%) patients there was no metastasis SLN. The sensitivity of the method was 91.2%, specificity of 100%. Conclusion: The specificity of SPECT with 199Tl was higher than that with 99mTc-MIBI. The data obtained show that SPECT with 199Tl can be recommended for its use as an additional breast cancer detection method in cases when other imaging techniques and histological findings are not accurate enough. The clinical study of 99mTc-Aloteh, a new radiopharmaceutical agent, has shown that the studied colloid has high uptake level in SLN and can be successfully used for visualization of SLN in patients with breast cancer. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 0 |
_0(RuTPU)RU\TPU\network\4816 _tAIP Conference Proceedings |
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| 463 | 0 |
_0(RuTPU)RU\TPU\network\24427 _tVol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17) _oProceedings of the International conference, 23–26 May 2017, Tomsk, Russia _fNational Research Tomsk Polytechnic University (TPU) ; eds. E. Y. Gutmanas, O. B. Naimark, Yu. P. Sharkeev _v[020070, 5 p.] _d2017 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aядерная медицина | |
| 610 | 1 | _aдиагностика | |
| 610 | 1 | _aрак | |
| 610 | 1 | _aмолочные железы | |
| 610 | 1 | _aопухоли | |
| 610 | 1 | _aлимфатическая система | |
| 610 | 1 | _aрадиофармацевтические препараты | |
| 610 | 1 | _aвизуализация | |
| 701 | 1 |
_aSinilkin _bI. G. _cspecialist in the field of medical technology _claboratory, Tomsk Polytechnic University, candidate of medical science _f1972- _gIvan Gennadjevich _2stltpush _3(RuTPU)RU\TPU\pers\34189 |
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| 701 | 1 |
_aMedvedeva _bА. А. _cspecialist in the field of medical technology _claboratory assistant of Tomsk Polytechnic University, candidate of medical science _f1975- _gAnna Aleksndrovna _2stltpush _3(RuTPU)RU\TPU\pers\37376 |
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| 701 | 1 |
_aChernov _bV. I. _cspecialist in the field of medical technology _clead engineer of Tomsk Polytechnic University, doctor of medical sciences _f1962- _gVladimir Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\34191 |
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| 701 | 1 |
_aSlonimskaya _bE. |
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| 701 | 1 |
_aZelchan (Zeltchan) _bR. V. _cspecialist in the field of medical technology _cResearcher of the Tomsk Polytechnic University, Candidate of Medical Sciences _f1984- _gRoman Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\34194 |
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| 701 | 1 |
_aBragina _bO. D. _cspecialist in the field of medical technology _cAssociate Scientist of Tomsk Polytechnic University, Candidate of medical Sciences _f1986- _gOlga Dmitrievna _2stltpush _3(RuTPU)RU\TPU\pers\35943 |
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| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bЛаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР) _h6471 _2stltpush _3(RuTPU)RU\TPU\col\20054 |
| 801 | 2 |
_aRU _b63413507 _c20210302 _gRCR |
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| 856 | 4 | _uhttps://doi.org/10.1063/1.5001649 | |
| 856 | 4 | _uhttp://earchive.tpu.ru/handle/11683/46887 | |
| 942 | _cCF | ||