| 000 | 03543nla2a2200517 4500 | ||
|---|---|---|---|
| 001 | 657746 | ||
| 005 | 20231030041524.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\24472 | ||
| 035 | _aRU\TPU\network\24471 | ||
| 090 | _a657746 | ||
| 100 | _a20180314a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 105 | _ay z 100zy | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aChemotherapy Changes Cytotoxic Activity of NK-cells in Cancer Patients _fM. Stakheyeva [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 17 tit.] | ||
| 330 | _aIn recent years, it has been shown that under certain conditions cytostatic agents (chemotherapy and radiotherapy) can restore the functioning of the immune system impaired by malignancy burden. The modifications of biological properties by cytostatics acting make cancer cells visible for the immune system recognition and elimination. Eighteen patients diagnosed with primary local breast (8) and gastric (10) cancer between 2014 and 2016 were enrolled in the investigation. The phenotypic features of NK were assessed by flow cytometry using mAb (BD Pharmingen) against CD45 (common leukocyte antigen) and CD56 (NK-marker) for surface staining, CD107a (LAMP-1), Perforin (PF) and Gransime B (GB) for intracellular staining. We examined NK populations in the peripheral blood of cancer patients before treatment and in 5 days after second course of NACT. We found that NK populations produced PF in cancer patents, which were absent before treatment, increased after NACT. Their emergence can be associated with the immunoactivating effects of chemotherapy, realized by the modification of tumor cells or elimination of immunosuppressive cells. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 0 |
_0(RuTPU)RU\TPU\network\4816 _tAIP Conference Proceedings |
|
| 463 | 0 |
_0(RuTPU)RU\TPU\network\24427 _tVol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17) _oProceedings of the International conference, 23–26 May 2017, Tomsk, Russia _fNational Research Tomsk Polytechnic University (TPU) ; eds. E. Y. Gutmanas, O. B. Naimark, Yu. P. Sharkeev _v[020072, 4 p.] _d2017 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aхимиотерапия | |
| 610 | 1 | _aрак | |
| 610 | 1 | _aлучевая терапия | |
| 610 | 1 | _aраспознавание | |
| 610 | 1 | _aимунная система | |
| 610 | 1 | _aбиологические свойства | |
| 610 | 1 | _aцитотоксические свойства | |
| 701 | 1 |
_aStakheyeva _bM. |
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| 701 | 1 |
_aYunusova _bN. |
|
| 701 | 1 |
_aPatysheva _bM. |
|
| 701 | 1 |
_aMitrofanova _bI. V. |
|
| 701 | 1 |
_aFaltin _bV. |
|
| 701 | 1 |
_aTuzikov _bS. |
|
| 701 | 1 |
_aSlonimskaya _bE. |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bЛаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР) _h6471 _2stltpush _3(RuTPU)RU\TPU\col\20054 |
| 712 | 0 | 2 |
_aNational Research Tomsk Polytechnic University (TPU) _2stltpush _3(RuTPU)RU\TPU\col\18773 |
| 801 | 2 |
_aRU _b63413507 _c20180321 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1063/1.5001651 | |
| 856 | 4 | _uhttp://earchive.tpu.ru/handle/11683/46888 | |
| 942 | _cCF | ||