| 000 | 03247nlm1a2200385 4500 | ||
|---|---|---|---|
| 001 | 658832 | ||
| 005 | 20231030041609.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\26956 | ||
| 090 | _a658832 | ||
| 100 | _a20181129a2018 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aFolic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents _fA. Di Martino [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: p. 76 (35 tit.)] | ||
| 330 | _aA major challenge faced by researchers involved in the sphere of drug delivery is the development of innovative multidrug delivery systems. Herein, experimentation focused on preparing nanocomplexes based on chitosan and alginic acid with the purpose of allocating a combination of chemotherapeutic drugs, improving their efficacy and reducing dosage. In order to enhance targeting, conjugation with folic acid was performed. The prepared carriers exhibited a spherical shape with a diameter in the range 70–120?nm, a ?-potential between 30 and 35?mV with good stability in human serum, and low hemolytic activity of up to 100??g/mL. Over 800??g of drugs per mg of carrier were loaded and released, displaying a pH-dependent trend with no physical, chemical and biological interferences, which benefited from the advantage of having full control over the given release of drug. In vitro studies performed on human epithelial cervix carcinoma cells and mouse fibroblast cells clearly demonstrated that said dual-loaded complexes showed greater cytotoxicity than single-loaded and free-drug formulations. The viability of the cells decreased, thereby confirming the primary role played by the targeting molecule. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 |
_tJournal of Drug Delivery Science and Technology _oScientific Journal |
||
| 463 |
_tVol. 47 _v[P. 67-76] _d2018 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aполисахариды | |
| 610 | 1 | _aфолиевая кислота | |
| 610 | 1 | _aтерапия | |
| 701 | 1 |
_aDi Martino _bA. _corganic chemist _cresearch of Tomsk Polytechnic University _f1984- _gAntonio _2stltpush _3(RuTPU)RU\TPU\pers\39440 |
|
| 701 | 1 |
_aTrusova _bM. E. _corganic chemist _cAssociate professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1982- _gMarina Evgenievna _2stltpush _3(RuTPU)RU\TPU\pers\31823 |
|
| 701 | 1 |
_aPostnikov _bP. S. _corganic chemist _cSenior Lecturer of Tomsk Polytechnic University, Candidate of chemical sciences _f1984- _gPavel Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\31287 |
|
| 701 | 1 |
_aSedlarik _bV. _gVladimir |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20181129 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.jddst.2018.06.020 | |
| 942 | _cCF | ||