| 000 | 03826nlm1a2200445 4500 | ||
|---|---|---|---|
| 001 | 659420 | ||
| 005 | 20231030041628.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\27979 | ||
| 090 | _a659420 | ||
| 100 | _a20190218a2018 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aAntibacterial Action of Mixed-ligand Imidazole - Phenanthroline Copper Complex _fE. V. Plotnikov, V. M. Plotnikov |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aBackground: Multidrug Resistance (MDR) of microorganisms is the biggest pharmacological challenge, despite plenty of modern antibiotics. Obviously, new classes of antimicrobial drugs against MDR pathogens need to be developed. Objective: This work aimed to investigate the antibacterial properties of the novel copper-based complex - bisimidazoles - (1,10) phenanthroline cuprum (II) dichloride - [CuPhenIm2]Cl2. Material & Methods: The complex - bisimidazoles-(1,10)phenanthroline cuprum (II) dichloride - [Cu- Phen-Im2]Cl2 was synthetized for the experiment. The structure was identified by elemental analysis and IR spectroscopy. The antibacterial properties of the copper complex were investigated by agar diffusion and serial dilution methods with the following bacteria strains Staphylococcus haemolyticus (ATCC 29970), Staphylococcus aureus (ATCC 25923), Proteus vulgaris (ATCC 13315), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Mycobacterium bovis (Valle). Antituberculosis activity test included evaluation of bacterial growth on Lowenstein Jensen media with a serial dilution of copper complex, within an observation period of 90 days. Results: The prospect copper complex showed significant antibacterial activity. The most susceptible to copper action were strains of S.haemolyticus and S.aureus. The bisimidazoles - (1,10) phenanthroline cuprum (II) dichloride revealed moderate bactericidal action against Mycobacteria bovis. Conclusion: Most of the tested bacterial pathogens were highly susceptible to the novel copper substance. A detailed assessment of the biological action in in vivo is further required. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tAnti-Infective Agents | ||
| 463 |
_tVol. 16, iss. 2 _v[P. 100-103] _d2018 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _acopper-based complex | |
| 610 | 1 | _aphenanthroline | |
| 610 | 1 | _aimidazoles | |
| 610 | 1 | _aantibacterial drug | |
| 610 | 1 | _astaphylococcus | |
| 610 | 1 | _amycobacterium bovis | |
| 610 | 1 | _aфенантролины | |
| 610 | 1 | _aимидазолы | |
| 610 | 1 | _aантибактериальные препараты | |
| 610 | 1 | _aстафилококки | |
| 700 | 1 |
_aPlotnikov _bE. V. _cchemist _cEngineer of Tomsk Polytechnic University _f1983- _gEvgeny Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\32469 |
|
| 701 | 1 |
_aPlotnikov _bV. M. _gVladimir Mikhaylovich |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа природных ресурсов _bОтделение химической инженерии _h8085 _2stltpush _3(RuTPU)RU\TPU\col\23513 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20190218 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.2174/2211352516666180531075622 | |
| 942 | _cCF | ||