000			04437nlm1a2200469 4500
001			659550
005			20231030041632.0
035			_a(RuTPU)RU\TPU\network\28160
035			_aRU\TPU\network\20090
090			_a659550
100			_a20190227a2018 k y0engy50 ba
101	0		_aeng
135			_adrcn ---uucaa
181		0	_ai
182		0	_ab
200	1		_aNitric oxide provides myocardial protection when added to the cardiopulmonary bypass circuit during cardiac surgery: Randomized trial _fN. O. Kamenshchikov [et al.]
203			_aText _celectronic
300			_aTitle screen
330			_aObjectives - The aim of this pilot study was to elucidate the effects of exogenous nitric oxide <https://www.sciencedirect.com/topics/medicine-and-dentistry/nitric-oxide>(NO) supply to the extracorporeal circulation <https://www.sciencedirect.com/topics/medicine-and-dentistry/extracorporeal-circulation> circuit for cardioprotection <https://www.sciencedirect.com/topics/medicine-and-dentistry/heart-protection> against -ischemiareperfusion injury <https://www.sciencedirect.com/topics/medicine-and-dentistry/reperfusion-injury> during coronary artery bypass grafting <https://www.sciencedirect.com/topics/medicine-and-dentistry/coronary-artery-bypass-graft> (CABG) with cardiopulmonary bypass <https://www.sciencedirect.com/topics/medicine-and-dentistry/cardiopulmonary-bypass> (CPB). Methods -A total of 60 patients with coronary artery disease <https://www.sciencedirect.com/topics/medicine-and-dentistry/coronary-artery-disease> scheduled for CABG with CPB were enrolled in a prospective randomized study. Patients were allocated randomly to receive treatment according to standard or modified CPB protocol where 40-ppm NO was added to the CPB circuit during cardiac surgery <https://www.sciencedirect.com/topics/medicine-and-dentistry/heart-surgery>. The primary endpoint was the measurement of cardiac troponin I <https://www.sciencedirect.com/topics/medicine-and-dentistry/troponin-i> (cTnI). The secondary end points consisted in the measurements of creatine kinase-muscle/brain fraction (CK-MB) and vasoactive inotropic <https://www.sciencedirect.com/topics/medicine-and-dentistry/inotropism> score (VIS).
330			_aResults - NO delivered into the CPB circuit had a cardioprotective effect. The level of cTnI was significantly lower in NO-treated group compared with the control group 6 hours after surgery: 1.79 ± 0.39 ng/mL versus 2.41 ± 0.55 ng/mL, respectively (P = .001). The CK-MB value was significantly lower in NO-treated group compared with the control group 24 hours after surgery: 47.69 ± 8.08 U/L versus 62.25 ± 9.78 U/L, respectively (P = .001); and the VIS was significantly lower in the NO-treated group 6 hours after the intervention. Conclusions - NO supply to the CPB circuit during CABG exerted a cardioprotective effect and was associated with lower levels of VIS and cardiospecific blood markers cTnI and CK-MB.
333			_aРежим доступа: по договору с организацией-держателем ресурса
461			_tThe Journal of Thoracic and Cardiovascular Surgery
463			_tVol. ХХХ _v[10 p.] _d2018
610	1		_aэлектронный ресурс
610	1		_aтруды учёных ТПУ
610	1		_acardioprotection
610	1		_aischemia-reperfusion injury
610	1		_anitric oxide
610	1		_acardiopulmonary bypass
610	1		_acoronary artery bypass grafting
610	1		_aшунтирование
610	1		_aоксид азота
610	1		_aишемия
701		1	_aKamenshchikov _bN. O. _gNikolay Olegovich
701		1	_aMandel _bI. A. _gIrina Arkadjevna
701		1	_aPodoksenov _bYu. K. _gYury Kirilovich
701		1	_aSvirko _bYu. S. _gYulia Stanislavovna
701		1	_aAnfinogenova _bYa. J. _cLinguist _cLecturer of Tomsk Polytechnic University, Doctor of medical sciences _f1970- _gYana Jonovna _2stltpush _3(RuTPU)RU\TPU\pers\33592
712	0	2	_aНациональный исследовательский Томский политехнический университет _bИнженерная школа новых производственных технологий _bНаучно-образовательный центр Н. М. Кижнера _h7872 _2stltpush _3(RuTPU)RU\TPU\col\23556
801		2	_aRU _b63413507 _c20190227 _gRCR
856	4		_uhttps://doi.org/10.1016/j.jtcvs.2018.08.117
942			_cCF