| 000 | 03734nlm1a2200481 4500 | ||
|---|---|---|---|
| 001 | 659697 | ||
| 005 | 20231030041638.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\28424 | ||
| 035 | _aRU\TPU\network\14847 | ||
| 090 | _a659697 | ||
| 100 | _a20190320a2018 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aPolymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia _fS. A. Ivanova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 44 tit.] | ||
| 330 | _aPurpose. Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID). The aim of this study is to investigate the association between seven COMT gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients with PD. Methods. 232 Caucasian patients with PD were investigated. 212 patients with PD received Levodopa therapy. Dyskinesia was assessed with the use of the Abnormal Involuntary Movement Scale (AIMS). Genotyping was carried out on seven SNPs of the COMT gene (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) using a real-time PCR method, and blind to the clinical status of the subjects. Results. We found association between four SNPs, rs165774, rs4818, rs4633, rs4680, and LID. When the duration of disease was added as a covariate in regression analysis, however, the results did not reach statistical significance. Only the additive model for rs165774 was found to be close to be statistical significance (OR = 1.627 [0.976–2.741], permutation p = 0.057). Conclusions. The results failed to clearly support a contribution of the studied polymorphisms; this may be related to a dominant relationship with the disease duration confounding the effect on the prevalence of LID. | ||
| 461 | _tJournal of Pharmacy and Pharmaceutical Sciences (JPPS) | ||
| 463 |
_tVol. 21 _v[P. 340-346] _d2018 |
||
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aгены | |
| 610 | 1 | _aполиморфизм | |
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 701 | 1 |
_aAlifirova _bV. M. _gValentina Mikhaylovna |
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| 701 | 1 |
_aPozhidaev _bI. V. _gIvan Vyacheslavovich |
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| 701 | 1 |
_aFreydin _bM. B. _gMaksim Borisovich |
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| 701 | 1 |
_aZhukova _bI. A. _gIrina Aleksandrovna |
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| 701 | 1 |
_aOsmanova _bD. Z. _gDiana Zakirovn |
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| 701 | 1 |
_aZhukova _bN. G. _gNataljya Grigorjevna |
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| 701 | 1 |
_aMironova _bYu. A. _gYuliya Aleksandrovna |
|
| 701 | 1 |
_aTiguntsev _bV. V. _gVladimir Vladimirovich |
|
| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
|
| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
|
| 701 | 1 |
_aWilffert _bB. _gBob |
|
| 701 | 1 |
_aLoonen _bA. J. M. _gAnton |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа неразрушающего контроля и безопасности _bОтделение контроля и диагностики _h7978 _2stltpush _3(RuTPU)RU\TPU\col\23584 |
| 801 | 2 |
_aRU _b63413507 _c20190320 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.18433/jpps29903 | |
| 942 | _cCF | ||