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100 _a20190702a2019 k y0engy50 ba
101 0 _aeng
_deng
102 _aUS
135 _adrcn ---uucaa
181 0 _ai
182 0 _ab
200 1 _aThe Role of Humoral Factors in Producing the Cardioprotective Effect of Remote Ischemic Preconditioning
_fE. S. Prokudina [et al.]
203 _aText
_celectronic
300 _aTitle screen
320 _a[References: 78 tit.]
330 _aThe humoral pathway mediating the cardioprotective effect of remote ischemic preconditioning has been demonstrated in various models: ischemia-reperfusion of the fore- and hindlimbs and liver and occlusion-reperfusion of the mesenteric and renal arteries. This review assesses humoral components in the formation and realization of the cardioprotective actions of remote ischemic preconditioning of the heart. Endogenous agonists of opioid receptors, arachidonic acid derivatives (prostanoids), agonists of cannabinoid and vanilloid receptors, calcitonin gene-related peptide, leukotrienes, and microRNA are all regarded as humoral components. Adenosine, which also has a role in mediating the cardioprotective effects of remote ischemic preconditioning, is regarded as a mediator between the humoral factor and cardiomyocytes. Knowledge of the role of humoral factors in mediating cardioprotection may be useful for developing methods and therapeutic agents to increase the resistance of the myocardium to ischemic-reperfusion damage.
333 _aРежим доступа: по договору с организацией-держателем ресурса
461 _tNeuroscience and Behavioral Physiology
_d1967-
463 _tVol. 49, iss. 3
_v[P. 289–298]
_d2019
610 1 _aэлектронный ресурс
610 1 _aтруды учёных ТПУ
610 1 _aremote ischemic preconditioning
610 1 _ahumoral factors
610 1 _acardioprotection
610 1 _aсердце
610 1 _aишемическая болезнь
701 1 _aProkudina
_bE. S.
_gEkaterina Sergeevna
701 1 _aMaslov
_bL. N.
_gLeonid Nikolaevich
701 1 _aJaggi
_bA. S.
_gAmteshwar Singh
701 1 _aPismenniy
_bD. S.
_gDmitry Sergeevich
701 1 _aVoronkov
_bN. S.
_gNikita Sergeevich
701 1 _aNesterov
_bE. A.
_cPhysicist, Specialist in the field of nuclear power engineering
_cResearcher of Tomsk Polytechnic University
_f1976-
_gEvgeny Alexandrovich
_2stltpush
_3(RuTPU)RU\TPU\pers\32657
712 0 2 _aНациональный исследовательский Томский политехнический университет (ТПУ)
_bФизико-технический институт (ФТИ)
_bЛаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР)
_h6471
_2stltpush
_3(RuTPU)RU\TPU\col\20054
801 2 _aRU
_b63413507
_c20190702
_gRCR
856 4 _uhttps://doi.org/10.1007/s11055-019-00731-1
942 _cCF