| 000 | 03986nlm1a2200469 4500 | ||
|---|---|---|---|
| 001 | 660507 | ||
| 005 | 20231030041712.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\29957 | ||
| 035 | _aRU\TPU\network\22211 | ||
| 090 | _a660507 | ||
| 100 | _a20190705a2019 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aGB | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aOxidation of a wood extractive betulin to biologically active oxo-derivatives using supported gold catalysts _fE. N. Kolobova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 60 tit.] | ||
| 330 | _aBetulin (90–94%) was extracted from birch with a non-polar solvent and recrystallized from 2-propanol. Liquid-phase oxidation of betulin aimed at obtaining its biologically active oxo-derivatives (betulone, betulonic and betulinic aldehydes), exhibiting e.g. antitumor, anti-inflammatory, antiparasitic, anticancer and anti-HIV properties, was demonstrated for the first time over gold-based catalysts. Gold was deposited on pristine TiO2 and the same support modified with ceria and lanthana, followed by pretreatment with a H2 or O2 atmosphere. The catalysts were characterized by XRD, BET, ICP, TEM, XPS, DRIFT CO, TPD of NH3 and CO2 methods. The nature of the support, type of modification and the pretreatment atmosphere through the metal–support interactions significantly influenced the average particle size of gold, its distribution and the electronic state of gold, as well as the acid–base properties and, thereby, the catalytic performance (activity and selectivity) in betulin oxidation. Au/La2O3/TiO2 pretreated in H2 displayed the highest catalytic activity in betulin oxidation among the studied catalysts with selectivities to betulone, betulonic and betulinic aldehydes of 42, 32 and 27%, respectively, at 69% conversion. Side reactions resulting in oligomerization/polymerization products occurred on the catalyst surface with the participation of strong acid sites, diminishing the yield of the desired compounds. The latter was improved by adding hydrotalcite with the basic properties to the reaction mixture containing the catalyst. Kinetic modelling through numerical data fitting was performed to quantify the impact of such side reactions and determine the values of rate constants. | ||
| 461 | _tGreen Chemistry | ||
| 463 |
_tVol. 21, iss. 14 _v[P. 3370-3382] _d2019 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aокисление | |
| 610 | 1 | _aбетулин | |
| 610 | 1 | _aоксосоединения | |
| 701 | 1 |
_aKolobova _bE. N. _cChemical Engineer _cdesign engineer of Tomsk Polytechnic University _f1989- _gEkaterina Nikolaevna _2stltpush _3(RuTPU)RU\TPU\pers\34488 |
|
| 701 | 1 |
_aPakrieva _bE. G. _cChemical Engineer _cEngineer of Tomsk Polytechnic University _f1989- _gEkaterina Germanovna _2stltpush _3(RuTPU)RU\TPU\pers\33273 |
|
| 701 | 1 |
_aCarabineiro _bS. S. A. _gSonia |
|
| 701 | 1 |
_aBogdanchikova _bN. _gNina |
|
| 701 | 1 |
_aKharlanov _bA. N. _gAndrey |
|
| 701 | 1 |
_aKazantsev _bS. O. _cspecialist in the field of material science _cengineer of Tomsk Polytechnic University _f1991- _gSergey Olegovich _2stltpush _3(RuTPU)RU\TPU\pers\35794 |
|
| 701 | 1 |
_aHemming _bJ. _gJarl |
|
| 701 | 1 |
_aArvela _bP. M. _gPдivi Mдki |
|
| 701 | 1 |
_aPestryakov _bA. N. _cChemist _cProfessor of Tomsk Polytechnic University, Doctor of Chemical Science _f1963- _gAleksey Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\30471 |
|
| 701 | 1 |
_aMurzin _bD. Yu. _gDmitry |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20190705 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1039/C9GC00949C | |
| 942 | _cCF | ||