| 000 | 03189nlm1a2200445 4500 | ||
|---|---|---|---|
| 001 | 660568 | ||
| 005 | 20231030041714.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\30092 | ||
| 090 | _a660568 | ||
| 100 | _a20190805a2019 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aInvestigation of the Size Distribution for Diffusion-Controlled Drug Release From Drug Delivery Systems of Various Geometries _fT. I. Spiridonova, S. I. Tverdokhlebov, Yu. G. Anissimov |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aVarious drug delivery systems (DDSs) are often used in modern medicine to achieve controlled and targeted drug release. Diffusional release of drugs from DDSs is often the main mechanism, especially at early times. Generally, average dimensions of DDS are used to model the drug release, but our recent work on drug release from fibers demonstrated that taking into account diameter distribution is essential. This work systematically investigated the effect of size distribution on diffusional drug release from DDSs of various geometric forms such as membranes, fibers, and spherical particles. The investigation clearly demonstrated that the size distribution has the largest effect on the drug release profiles from spherical particles compared to other geometric forms. Published experimental data for drug release from polymer microparticles and nanoparticles were fitted, and the diffusion coefficients were determined assuming reported radius distributions. Assuming the average radius when fitting the data leads to up to 5 times underestimation of the diffusion coefficient of drug in the polymer. | ||
| 461 | _tJournal of Pharmaceutical Sciences | ||
| 463 |
_tVol. 108, iss. 8 _v[P. 2690-2697] _d2019 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _amathematical modeling | |
| 610 | 1 | _adiffusion | |
| 610 | 1 | _adrug delivery systems | |
| 610 | 1 | _acontrolled drug release | |
| 610 | 1 | _ananoparticles | |
| 610 | 1 | _amicroparticles | |
| 610 | 1 | _aматематическое моделирование | |
| 610 | 1 | _aдиффузии | |
| 610 | 1 | _aлекарства | |
| 610 | 1 | _aнаночастицы | |
| 610 | 1 | _aмикрочастицы | |
| 700 | 1 |
_aSpiridonova _bT. I. _cspecialist in the field of material science _cEngineer of Tomsk Polytechnic University _f1994- _gTatjyana Igorevna _2stltpush _3(RuTPU)RU\TPU\pers\43141 |
|
| 701 | 1 |
_aTverdokhlebov _bS. I. _cphysicist _cAssociate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science _f1961- _gSergei Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\30855 |
|
| 701 | 1 |
_aAnissimov _bYu. G. _gYuri |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа ядерных технологий _bНаучно-образовательный центр Б. П. Вейнберга _h7866 _2stltpush _3(RuTPU)RU\TPU\col\23561 |
| 801 | 2 |
_aRU _b63413507 _c20190805 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.xphs.2019.03.036 | |
| 942 | _cCF | ||