| 000 | 03828nlm1a2200517 4500 | ||
|---|---|---|---|
| 001 | 660989 | ||
| 005 | 20231030041730.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\31193 | ||
| 035 | _aRU\TPU\network\26957 | ||
| 090 | _a660989 | ||
| 100 | _a20191114a2019 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aChitosan-collagen based film for controlled delivery of a combination of short life anesthetics _fA. Di Martino, A. A. Drannikov, N. S. Surgutskaya [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 42 tit.] | ||
| 330 | _aThe present research was undertaken to develop a chitosan-collagen film for controlled delivery of combinations of local anesthetics. The film has been prepared by casting which is a versatile, rapid and low-cost approach distinguished by high reproducibility. The mechanical, morphological, and physicochemical properties of the films and the impact of the drug loading were evaluated. We showed that the formulations have a good combination of strength and flexibility with high water permeability. Surface morphology investigation indicates a variation in roughness depending on the loaded compound. Release studies were performed in controlled environments and the data processed by the Higuchi model to assess the dynamics of the release. The local anesthetics, lidocaine, tetracaine, and benzocaine, were uniformly distributed within the matrix and released in a rate and magnitude specific for the drug concentration and combination tunable in a range time from 6?h to 24?h. The films dissolve completely in the physiological environment within 24?h without leaving any toxic metabolites as both of the components are recognized as safe. In vitro cytotoxicity and cell proliferation tests performed on human dermal fibroblast demonstrate the biocompatibility and lack of cytotoxicity of the prepared formulations. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tInternational Journal of Biological Macromolecules | ||
| 463 |
_tVol. 140 _v[P. 1183-1193] _d2019 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _achitosan | |
| 610 | 1 | _acollagen | |
| 610 | 1 | _alocal anesthetic | |
| 610 | 1 | _afilm | |
| 610 | 1 | _adrug delivery | |
| 610 | 1 | _aхитозан | |
| 610 | 1 | _aколлаген | |
| 610 | 1 | _aанестетики | |
| 610 | 1 | _aдоставка | |
| 610 | 1 | _aлекарства | |
| 701 | 1 |
_aDi Martino _bA. _corganic chemist _cresearch of Tomsk Polytechnic University _f1984- _gAntonio _2stltpush _3(RuTPU)RU\TPU\pers\39440 |
|
| 701 | 1 |
_aDrannikov _bA. A. _cchemist _cengineer of Tomsk Polytechnic University _f1994- _gAleksandr Alekseevich _2stltpush _3(RuTPU)RU\TPU\pers\47466 |
|
| 701 | 1 |
_aSurgutskaya _bN. S. _gNataljya |
|
| 701 | 1 |
_aOzaltin _bK. _gKadir |
|
| 701 | 1 |
_aPostnikov _bP. S. _corganic chemist _cSenior Lecturer of Tomsk Polytechnic University, Candidate of chemical sciences _f1984- _gPavel Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\31287 |
|
| 701 | 1 |
_aTrusova _bM. E. _corganic chemist _cAssociate professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1982- _gMarina Evgenievna _2stltpush _3(RuTPU)RU\TPU\pers\31823 |
|
| 701 | 1 |
_aSedlarik _bV. _gVladimir |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20230125 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.ijbiomac.2019.08.228 | |
| 942 | _cCF | ||