| 000 | 02833nlm1a2200433 4500 | ||
|---|---|---|---|
| 001 | 661353 | ||
| 005 | 20231030041743.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\31696 | ||
| 035 | _aRU\TPU\network\15997 | ||
| 090 | _a661353 | ||
| 100 | _a20191203a2018 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aCompartmental modeling of skin transport _fA. A. Amaraha [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 56 tit.] | ||
| 330 | _aThe primary objective of this study is to introduce a simple and flexible mathematical approach which models transport processes in skin using compartments. The main feature of the presented approach is that the rate constants for exchange between compartments are derived from physiologically relevant diffusional transport parameters. This allows for better physical interpretation of the rate constants, and limits the number of parameters for the compartmental model. The resulting compartmental solution is in good agreement with previously published solutions for the diffusion model of skin when ten or more compartments are used. It was found that the new compartmental model with three compartments provided a better fit of the previously publish water penetration data than the diffusion model. Two special cases for which it is difficult to implement the diffusion model were considered using our compartmental approach. In both cases the compartmental model predictions agreed well with the diffusion model. | ||
| 461 | _tEuropean Journal of Pharmaceutics and Biopharmaceutics | ||
| 463 |
_tVol. 130 _v[P. 336-344] _d2018 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _askin transport | |
| 610 | 1 | _acompartmental model | |
| 610 | 1 | _adiffusion model | |
| 610 | 1 | _aкомпартментальные модели | |
| 610 | 1 | _aдиффузионные модели | |
| 701 | 1 |
_aAmaraha _bA. A. |
|
| 701 | 1 |
_aPetlin _bD. G. _cphysicist _cTechniques of Tomsk Polytechnic University _f1990- _gDaniil Gennadyevich _2stltpush _3(RuTPU)RU\TPU\pers\30858 |
|
| 701 | 1 |
_aGrice _bJ. E. _gJeffrey |
|
| 701 | 1 |
_aHadgrafte _bJ. |
|
| 701 | 1 |
_aRoberts _bM. S. |
|
| 701 | 1 |
_aAnissimov _bYu. G. _gYuri German |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bКафедра химической технологии редких, рассеянных и радиоактивных элементов (№ 43) (ХТРЭ) _h56 _2stltpush _3(RuTPU)RU\TPU\col\18733 |
| 801 | 2 |
_aRU _b63413507 _c20191203 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.ejpb.2018.07.015 | |
| 942 | _cCF | ||