| 000 | 03290nlm1a2200577 4500 | ||
|---|---|---|---|
| 001 | 661660 | ||
| 005 | 20231030041754.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\32384 | ||
| 035 | _aRU\TPU\network\14181 | ||
| 090 | _a661660 | ||
| 100 | _a20200127a2019 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_apH-triggered delivery of magnetic nanoparticles depends on tumor volume _fA. G. Pershina [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 30 tit.] | ||
| 330 | _aNowadays there is growing recognition of the fact that biological systems have a greater impact on nanoparticle target delivery in tumors than nanoparticle design. Here we investigate the targeted delivery of Fe3O4 magnetic nanoparticles conjugated with pH-low-insertion peptide (MNP-pHLIP) on orthotopically induced MDA-MB-231 human breast carcinoma xenografts of varying volumes as a model of cancer progression. Using in vivo magnetic resonance imaging and subsequent determination of iron content in tumor samples by inductively coupled plasma atomic emission spectroscopy we found that MNP-pHLIP accumulation depends on tumor volume. Transmission electron microscopy, histological analysis and immunohistochemical staining of tumor samples suggest that blood vessel distribution is the key factor in determining the success of the accumulation of nanoparticles in tumors. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tNanomedicine: Nanotechnology, Biology and Medicine | ||
| 463 |
_tVol. 23 _v[102086, 8 p.] _d2019 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _apHLIP | |
| 610 | 1 | _airon oxide magnetic nanoparticle | |
| 610 | 1 | _atumor | |
| 610 | 1 | _aMRI | |
| 610 | 1 | _atargeting | |
| 610 | 1 | _aМРТ | |
| 610 | 1 | _aопухоли | |
| 701 | 1 |
_aPershina _bA. G. _cbiologist _cAssociate Professor of Tomsk Polytechnic University, Candidate of biological sciences _f1981- _gAleksandra Gennadievna _2stltpush _3(RuTPU)RU\TPU\pers\32466 |
|
| 701 | 1 |
_aBrikunova _bO. Ya. _gOlga Yaroslavovna |
|
| 701 | 1 |
_aDemin _bA. M. _gAleksandr Mikhaylovich |
|
| 701 | 1 |
_aShevelev _bO. B. _gOleg Borisovich |
|
| 701 | 1 |
_aRazumov _bI. A. _gIvan Alekseevich |
|
| 701 | 1 |
_aZavjyalov _bE. L. _gEvgeny Leonidovich |
|
| 701 | 1 |
_aMalkeeva _bD. _gDina |
|
| 701 | 1 |
_aKiseleva _bE. V. _gElena Vladimirovna |
|
| 701 | 1 |
_aKrakhmal _bN. V. _gNadezhda Valerjevna |
|
| 701 | 1 |
_aVtorushin _bS. V. _gSergey Vladimirovich |
|
| 701 | 1 |
_aYarnykh _bV. L. _gVasily |
|
| 701 | 1 |
_aIvanov _bV. V. _gVladimir Vladimirovich |
|
| 701 | 1 |
_aPleshko _bR. I. _gRaisa Ivanovna |
|
| 701 | 1 |
_aKrasnov _bV. P. _gViktor Pavlovich |
|
| 701 | 1 |
_aOgorodova _bL. M. _gLyudmila Mikhaylovna |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20200127 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.nano.2019.102086 | |
| 942 | _cCF | ||