| 000 | 04146nlm1a2200469 4500 | ||
|---|---|---|---|
| 001 | 662558 | ||
| 005 | 20231030041825.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\33713 | ||
| 090 | _a662558 | ||
| 100 | _a20200903a2020 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aNL | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aDosimetric and radiobiological comparison of simultaneous integrated boost and sequential boost of locally advanced cervical cancer _fE. S. Sukhikh, L. G. Sukhikh, P. A. Lushnikova [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 25 tit.] | ||
| 330 | _aIntroduction Some patients with locally advanced cervical cancer (LACC) cannot undergo brachytherapy (BT). Possible treatment includes two-stage external beam radiotherapy (sequential boost - SEQ) or single-stage external beam radiotherapy (simultaneous integrated boost - SIB). The goal of this paper was to carry out dosimetric and radiobiological comparison of these techniques with respect to tumour and organs-at-risk (OARs) irradiation. Methods The anatomic data of six patients with LACC were used for this study. The single-stage SIB-VMAT (25, 27 or 30 fractions) and double-stage SEQ-VMAT (25 + 6 fractions) plans were developed to deliver EQD2=50 Gy to the pelvic region and EQD2=90 Gy to the tumour. The developed plans were compared with respect to an EQD2 dose delivered to a tumour and to the OARs, expected tumour control probability and normal tissue complications probability. Results The developed SIB-VMAT and SEQ-VMAT plans had physical coverage of the CTV tumours with more than 95% of the prescribed dose delivered to more than 95% of the volume. The irradiation of the tumour for both SIB-VMAT and SEQ-VMAT has comparable EQD2 values close to 87-88 Gy. SIB-VMAT treatment plans provided lower levels of irradiation of OARs than SEQ-VMAT plans. The optimal number of fractions for SIB-VMAT was 27. Conclusion SIB-VMAT is a better treatment option for patients with LACC that are not eligible for BT. Results show that both SIB-VMAT and SEQ-VMAT allowed good coverage of the tumour and high-quality dose delivery. SIB-VMAT allowed minimising irradiation of OARs and shortening the overall treatment time by a week. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tPhysica Medica | ||
| 463 |
_tVol. 73 _v[P. 83-88] _d2020 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aprostate cancer | |
| 610 | 1 | _alocally advanced cervical cancer | |
| 610 | 1 | _avolumetric modulated arc therapy | |
| 610 | 1 | _asimultaneous integrated boost | |
| 610 | 1 | _aрак | |
| 610 | 1 | _aмодулированные методы | |
| 610 | 1 | _aлучевая терапия | |
| 701 | 1 |
_aSukhikh _bE. S. _cspecialist in the field of nuclear energy _cEngineer of Tomsk Polytechnic University _f1986- _gEvgeniya Sergeevna _2stltpush _3(RuTPU)RU\TPU\pers\31215 |
|
| 701 | 1 |
_aSukhikh _bL. G. _cphysicist _cResearcher of Tomsk Polytechnic University, Candidate of physical and mathematical sciences _f1984- _gLeonid Grigorievich _2stltpush _3(RuTPU)RU\TPU\pers\31554 |
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| 701 | 1 |
_aLushnikova _bP. A. |
|
| 701 | 1 |
_aTatarchenko _bM. A. _gMariya Alekseevna |
|
| 701 | 1 |
_aSalem _bA. R. A. _gAkhmed Ramadan Abdelrakhman |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа ядерных технологий _bОтделение ядерно-топливного цикла _h7864 _2stltpush _3(RuTPU)RU\TPU\col\23554 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа физики высокоэнергетических процессов _c(2017- ) _h8118 _2stltpush _3(RuTPU)RU\TPU\col\23551 |
| 801 | 2 |
_aRU _b63413507 _c20200903 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.ejmp.2020.04.012 | |
| 942 | _cCF | ||