| 000 | 03409nlm1a2200469 4500 | ||
|---|---|---|---|
| 001 | 662600 | ||
| 005 | 20231030041826.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\33755 | ||
| 035 | _aRU\TPU\network\28277 | ||
| 090 | _a662600 | ||
| 100 | _a20200908a2020 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aAssociation of ANKK1 polymorphism with antipsychotic‐induced hyperprolactinemia _fO. Yu. Fedorenko, D. Z. Paderina, A. J. M. Loonen [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 330 | _aObjective: Schizophrenia is a severe highly heritable mental disorder. Genetic polymorphisms of dopaminergic pathways are related to pathogenesis of drug response. Hyperprolactinemia (HPRL), a common adverse effect of antipsychotics, is attributed to blockade of dopamine D2 receptors. Ankyrin Repeat and Kinase Domain containing 1 (ANKK1) gene is closely related to Dopamine Receptor D2 type (DRD2) gene functioning. We examined whether the functional polymorphism rs2734849 in the ANKK1 gene is associated with antipsychotic?induced HPRL. Methods: We recruited 446 patients with schizophrenia from among the Russian population of the Siberian region. The polymorphism rs2734849 in the ANKK1 gene was genotyped with The MassARRAY® Analyzer 4 by Agena Bioscience™, using the kit SEQUENOM Consumables iPLEXGold 384. Genotype and allele frequencies were compared between groups of schizophrenia patients with and without HPRL using the ?2 test. Results: A comparison between schizophrenia patients with and without HPRL revealed significantly higher frequency of the C allele of the polymorphic variant rs2734849 in the ANKK1 gene in patients with HPRL as compared to the patients without it (?2 = 3.70; p = .05; odds ratio [OR] = 1.30 [0.99–1.69]). | ||
| 461 | _tHuman Psychopharmacology: Clinical and Experimental | ||
| 463 |
_tVol. 35, iss. 4 _v[e2737, 8 p.] _d2020 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aANKK1 | |
| 610 | 1 | _ahyperprolactinemia | |
| 610 | 1 | _apolymorphism | |
| 610 | 1 | _aschizophrenia | |
| 610 | 1 | _aполиморфизм | |
| 610 | 1 | _aшизофрения | |
| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
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| 701 | 1 |
_aPaderina _bD. Z. _gDiana |
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| 701 | 1 |
_aLoonen _bA. J. M. _gAnton |
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| 701 | 1 |
_aPozhidaev _bI. V. _gIvan |
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| 701 | 1 |
_aBoyko _bA. S. |
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| 701 | 1 |
_aKornetova _bE. G. _gElena Georgievna |
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| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
|
| 701 | 1 |
_aWilffert _bB. _gBob |
|
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа неразрушающего контроля и безопасности _bОтделение контроля и диагностики _h7978 _2stltpush _3(RuTPU)RU\TPU\col\23584 |
| 801 | 2 |
_aRU _b63413507 _c20200908 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1002/hup.2737 | |
| 942 | _cCF | ||