000			04277nlm1a2200445 4500
001			662843
005			20231030041834.0
035			_a(RuTPU)RU\TPU\network\34001
035			_aRU\TPU\network\18017
090			_a662843
100			_a20201111a2020 k y0engy50 ba
101	0		_aeng
102			_aGB
135			_adrcn ---uucaa
181		0	_ai
182		0	_ab
200	1		_aSite-specific release of reactive oxygen species from ordered arrays of microchambers based on polylactic acid and carbon nanodots _fA. V. Ermakov, V. L. Kudryavtseva, P. A. Demina [et al.]
203			_aText _celectronic
300			_aTitle screen
320			_a[References: 55 tit.]
330			_aNon-destructive, controllable, remote light-induced release inside cells enables studying of time- and space-specific surface-mediated delivery of bioactive compounds, which is an important approach in a wide range of biomedical tasks, especially those related to the control of cell growth, regenerative medicine, and self-disinfecting structures such as catheters. In this regard, the elaboration of encapsulation and controlled release of oxidative species is in high demand due to its versatile applications. One of the obvious candidates for such species is hydrogen peroxide. However, the delivery of hydrogen peroxide to the site of interest with high temporal and spatial precision remains challenging due to the active and unstable nature of the substance. We hereby present an approach to encapsulate and store a hydrogen peroxide-containing solid compound (sodium percarbonate) in the free-standing arrays of biopolymer-based microchambers. In this regard, we use solid-state encapsulation enabling high payload ability, followed by isolated storage in order to prevent contact of the cargo with water. Monitoring of the release profiles reveals the encapsulation of sodium percarbonate with little leakage for up to 24 hours.
330			_aMicrochambers are fabricated with predetermined size and spatial distribution, which allows the release of extremely small amounts of cargo (10-30 pg) with high spatial accuracy. Microchambers are made of polylactic acid and functionalized by carbon nanodots, which provide biocompatibility and biodegradability of the whole system together with responsiveness towards NIR light. These chambers facilitate both ultrasound-assisted burst release and laser-driven carbon nanoparticle-assisted precise release of extremely small, controlled amounts of a few picograms of hydrogen peroxide in submerged conditions. Microchambers loaded with sodium percarbonate provided adhesion and high viability of mouse fibroblasts over 24 h of exposure. The developed system opens an exciting avenue for prospective delivery routes in a number of areas such as wound healing by time and site-specific release.
333			_aРежим доступа: по договору с организацией-держателем ресурса
461			_tJournal of Materials Chemistry B
463			_tVol. 8, iss. 35 _v[P. 7977-7986] _d2020
610	1		_aэлектронный ресурс
610	1		_aтруды учёных ТПУ
701		1	_aErmakov _bA. V. _gAleksey Vadimovich
701		1	_aKudryavtseva _bV. L. _cphysicist _cEngineer of Tomsk Polytechnic University _f1993- _gValeriya Lvovna _2stltpush _3(RuTPU)RU\TPU\pers\38564
701		1	_aDemina _bP. A. _gPolina Anatoljevna
701		1	_aVerkhovsky _bR. A. _gRoman Anatoljevich
701		0	_aZhang Jiaxin
701		1	_aLengert _bE. V. _gEkaterina Vladimirovna
701		1	_aSapelkin _bA. _gAndrei
701		1	_aGoryacheva _bI. Yu. _gIrina Yuryevna
701		1	_aSukhorukov _bG. B. _cchemist _cThe Head of the Laboratory of Tomsk Polytechnic University, Candidate of physical and mathematical sciences _f1969- _gGleb Borisovich _2stltpush _3(RuTPU)RU\TPU\pers\37353
712	0	2	_aНациональный исследовательский Томский политехнический университет _bИнженерная школа ядерных технологий _bНаучно-образовательный центр Б. П. Вейнберга _h7866 _2stltpush _3(RuTPU)RU\TPU\col\23561
801		2	_aRU _b63413507 _c20201111 _gRCR
856	4		_uhttps://doi.org/10.1039/D0TB01148G
942			_cCF