| 000 | 04568nlm1a2200589 4500 | ||
|---|---|---|---|
| 001 | 662872 | ||
| 005 | 20231030041835.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\34031 | ||
| 035 | _aRU\TPU\network\18263 | ||
| 090 | _a662872 | ||
| 100 | _a20201119a2020 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aNL | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aMagnetron plasma mediated immobilization of hyaluronic acid for the development of functional double-sided biodegradable vascular graft _fV. L. Kudryavtseva, K. S. Stankevich, A. I. Kozelskaya [et al.] |
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| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 48 tit.] | ||
| 330 | _aThe clinical need for vascular grafts is associated with cardiovascular diseases frequently leading to fatal outcomes. Artificial vessels based on bioresorbable polymers can replace the damaged vascular tissue or create a bypass path for blood flow while stimulating regeneration of a blood vessel in situ. However, the problem of proper conditions for the cells to grow on the vascular graft from the adventitia while maintaining its mechanical integrity of the luminal surface remains a challenge. In this work, we propose a two-stage technology for processing electrospun vascular graft from polycaprolactone, which consists of plasma treatment and subsequent immobilization of hyaluronic acid on its surface producing thin double-sided graft with one hydrophilic and one hydrophobic side. Plasma modification activates the polymer surfaces and produces a thin layer for linker-free immobilisation of bioactive molecules, thereby producing materials with unique properties. Proposed modification does not affect the morphology or mechanical properties of the graft and improves cell adhesion. The proposed approach can potentially be used for various biodegradable polymers such as polylactic acid, polyglycolide and their copolymers and blends, with a hydrophilic inner surface and a hydrophobic outer surface. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tApplied Surface Science | ||
| 463 |
_tVol. 529 _v[147196, 9 p.] _d2020 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _apolycaprolactone | |
| 610 | 1 | _ahyaluronic acid | |
| 610 | 1 | _aplasma | |
| 610 | 1 | _aelectrospinning | |
| 610 | 1 | _avascular graft | |
| 610 | 1 | _asuperhydrophilicity | |
| 610 | 1 | _aполикапролактон | |
| 610 | 1 | _aгиалуроновая кислота | |
| 610 | 1 | _aплазма | |
| 610 | 1 | _aэлектроспиннинг | |
| 610 | 1 | _aтрансплантаты | |
| 701 | 1 |
_aKudryavtseva _bV. L. _cphysicist _cEngineer of Tomsk Polytechnic University _f1993- _gValeriya Lvovna _2stltpush _3(RuTPU)RU\TPU\pers\38564 |
|
| 701 | 1 |
_aStankevich _bK. S. _cPhysicist _cEngineer Tomsk Polytechnic University _f1992- _gKsenia Sergeevna _2stltpush _3(RuTPU)RU\TPU\pers\37546 |
|
| 701 | 1 |
_aKozelskaya _bA. I. _cphysicist _cAssistant of Tomsk Polytechnic University, Candidate of physical and mathematical sciences _f1985- _gAnna Ivanovna _2stltpush _3(RuTPU)RU\TPU\pers\39663 |
|
| 701 | 1 |
_aKibler _bE. V. _cspecialist in the field of nuclear technologies _cEngineer of Tomsk Polytechnic University _f1995- _gElina Vitaljevna _2stltpush _3(RuTPU)RU\TPU\pers\46672 |
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| 701 | 1 |
_aZhukov _bYu. M. _gYuriy Mikhaylovich |
|
| 701 | 1 |
_aMalashicheva _bA. B. _gAnna Borisovna |
|
| 701 | 1 |
_aGolovkin _bA. S. _gAleksey Sergeevich |
|
| 701 | 1 |
_aMishanin _bA. I. _gAleksandr Igorevich |
|
| 701 | 1 |
_aFilimonov _bV. D. _cRussian chemist _cProfessor of the TPU _f1945- _gViktor Dmitrievich _2stltpush _3(RuTPU)RU\TPU\pers\26423 |
|
| 701 | 1 |
_aBolbasov _bE. N. _cphysicist _cAssociate Scientist of Tomsk Polytechnic University, Candidate of Sciences _f1981- _gEvgeny Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\30857 |
|
| 701 | 1 |
_aTverdokhlebov _bS. I. _cphysicist _cAssociate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science _f1961- _gSergei Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\30855 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bКафедра экспериментальной физики (ЭФ) _h7596 _2stltpush _3(RuTPU)RU\TPU\col\21255 |
| 801 | 2 |
_aRU _b63413507 _c20201119 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.apsusc.2020.147196 | |
| 942 | _cCF | ||