| 000 | 04087nlm1a2200493 4500 | ||
|---|---|---|---|
| 001 | 662913 | ||
| 005 | 20231030041837.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\34072 | ||
| 035 | _aRU\TPU\network\33800 | ||
| 090 | _a662913 | ||
| 100 | _a20201219a2020 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aMultiresponsive Hybrid Microparticles for Stimuli-Responsive Delivery of Bioactive Compounds _fS. S. Vlasov, P. S. Postnikov, M. V. Belousov [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 42 tit.] | ||
| 330 | _aHybrid microparticles based on an iron core and an amphiphilic polymeric shell have been prepared to respond simultaneously to magnetic and ultrasonic fields and variation in the surrounding pH to trigger and modulate the delivery of doxorubicin. The microparticles have been developed in four steps: (i) synthesis of the iron core; (ii) surface modification of the core; (iii) conjugation with the amphiphilic poly(lactic acid)-grafted chitosan; and (iv) doxorubicin loading. The particles demonstrate spherical shape, a size in the range of 1–3 µm and surface charge that is tuneable by changing the pH of the environment. The microparticles demonstrate good stability in simulated physiological solutions and are able to hold up to 400 µg of doxorubicin per mg of dried particles. The response to ultrasound and the changes in the shell structure during exposure to different pH levels allows the control of the burst intensity and release rate of the payload. Additionally, the magnetic response of the iron core is preserved despite the polymer coat. In vitro cytotoxicity tests performed on fibroblast NIH/3T3 demonstrate a reduction in the cell viability after administration of doxorubicin-loaded microparticles compared to the administration of free doxorubicin. The application of ultrasound causes a burst in the release of the doxorubicin from the carrier, causing a decrease in cell viability. The microparticles demonstrate in vitro cytocompatibility and hemocompatibility at concentrations of up to 50 and 60 µg/mL, respectively. | ||
| 461 | _tApplied Sciences | ||
| 463 |
_tVol. 10, iss. 12 _v[4324, 14 p.] _d2020 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _acore–shell microparticles | |
| 610 | 1 | _aultrasound | |
| 610 | 1 | _aamphiphilic polymers | |
| 610 | 1 | _amagnetic microparticles | |
| 610 | 1 | _adoxorubicin | |
| 610 | 1 | _aмикрочастицы | |
| 610 | 1 | _aультразвук | |
| 610 | 1 | _aамфифильные структуры | |
| 610 | 1 | _aдоксорубицин | |
| 701 | 1 |
_aVlasov _bS. S. _gSergey Sergeevich |
|
| 701 | 1 |
_aPostnikov _bP. S. _corganic chemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1984- _gPavel Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\31287 |
|
| 701 | 1 |
_aBelousov _bM. V. _cchemist _cProfessor of Tomsk Polytechnic University, Doctor of Pharmaceutical Sciences _f1963- _gMikhail Valerievich _2stltpush _3(RuTPU)RU\TPU\pers\45418 |
|
| 701 | 1 |
_aKrivoshchekov _bS. V. _cchemist _cengineer of Tomsk Polytechnic University _f1987- _gSergey Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\34574 |
|
| 701 | 1 |
_aYusubov _bM. S. _cchemist _cProfessor of Tomsk Polytechnic University, Doctor of chemical sciences _f1961- _gMekhman Suleiman-Ogly (Suleimanovich) _2stltpush _3(RuTPU)RU\TPU\pers\31833 |
|
| 701 | 1 |
_aGurjev _bA. M. _gArtem Mikhaylovich |
|
| 701 | 1 |
_aDi Martino _bA. _corganic chemist _cresearch of Tomsk Polytechnic University _f1984- _gAntonio _2stltpush _3(RuTPU)RU\TPU\pers\39440 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20201219 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.3390/app10124324 | |
| 942 | _cCF | ||