| 000 | 03684nlm1a2200433 4500 | ||
|---|---|---|---|
| 001 | 663489 | ||
| 005 | 20231030041856.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\34659 | ||
| 035 | _aRU\TPU\network\34591 | ||
| 090 | _a663489 | ||
| 100 | _a20210216a2020 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aNeuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia _fM. B. Plotnikov, G. A. Chernysheva, V. A. Smolyakova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 52 tit.] | ||
| 330 | _aA novel specific inhibitor of c-Jun N-terminal kinase, 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S), has a high affinity to JNK3 compared to JNK1/JNK2. The aim of this work was to study the mechanisms of neuroprotective activity of IQ-1S in the models of reversible focal cerebral ischemia (FCI) in Wistar rats. The animals were administered with an intraperitoneal injection of IQ-1S (5 and 25 mg/kg) or citicoline (500 mg/kg). Administration of IQ-1S exerted a pronounced dose-dependent neuroprotective effect, not inferior to the effects of citicoline. Administration of IQ-1S at doses of 5 and 25 mg/kg reduced the infarct size by 20% and 50%, respectively, 48 h after FCI, whereas administration of citicoline reduced the infarct size by 34%. The administration of IQ-1S was associated with a faster amelioration of neurological status. Control rats showed a 2.0-fold increase in phospho-c-Jun levels in the hippocampus compared to the corresponding values in sham-operated rats 4 h after FCI. Administration of IQ-1S at a dose of 25 mg/kg reduced JNK-dependent phosphorylation of c-Jun by 20%. Our findings suggest that IQ-1S inhibits JNK enzymatic activity in the hippocampus and protects against stroke injury when administered in the therapeutic and prophylactic regimen in the rat model of FCI. | ||
| 461 | _tCells | ||
| 463 |
_tVol. 9, iss. 8 _v[1860, 12 p.] _d2020 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aPlotnikov _bM. B. _gMark Borisovich |
|
| 701 | 1 |
_aChernysheva _bG. A. _gGalina Anatoljevna |
|
| 701 | 1 |
_aSmolyakova _bV. A. _gVeronika Alekseevna |
|
| 701 | 1 |
_aAliev _bO. I. _gOleg Ibragimovich |
|
| 701 | 1 |
_aTrofimova _bE. S. _gEvgeniya Sergeevna |
|
| 701 | 1 |
_aSherstoboev _bE. Yu. _gEgeny Yurjevich |
|
| 701 | 1 |
_aOsipenko _bA. N. _gAnton Nikolaevich |
|
| 701 | 1 |
_aKhlebnikov _bA. I. _cChemist _cProfessor of Tomsk Polytechnic University _f1963- _gAndrey Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\33927 |
|
| 701 | 1 |
_aAnfinogenova _bYa. J. _cLinguist _cLecturer of Tomsk Polytechnic University, Doctor of medical sciences _f1970- _gYana Jonovna _2stltpush _3(RuTPU)RU\TPU\pers\33592 |
|
| 701 | 1 |
_aSchepetkin (Shchepyotkin) _bI. A. _cdoctor-biophysicist _cleading researcher of Tomsk Polytechnic University, candidate of medical science _f1962- _gIgor Aleksandrovich _2stltpush _3(RuTPU)RU\TPU\pers\37358 |
|
| 701 | 1 |
_aAtochin _bD. N. _cneuroscientist _cThe Head of the Laboratory of Tomsk Polytechnic University _f1960- _gDmitry Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\37514 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа новых производственных технологий _bНаучно-образовательный центр Н. М. Кижнера _h7872 _2stltpush _3(RuTPU)RU\TPU\col\23556 |
| 801 | 2 |
_aRU _b63413507 _c20210216 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.3390/cells9081860 | |
| 942 | _cCF | ||