| 000 | 02875nlm1a2200469 4500 | ||
|---|---|---|---|
| 001 | 663746 | ||
| 005 | 20231030041905.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\34916 | ||
| 090 | _a663746 | ||
| 100 | _a20210303a2020 k y0engy50 ba | ||
| 101 | 1 |
_aeng _deng |
|
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aCurrent outlook on radionuclide delivery systems: from design consideration to translation into clinics _fA. O. Peltek, A. R. Muslimov, M. V. Zyuzin, A. S. Timin |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 255 tit.] | ||
| 330 | _aRadiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed. | ||
| 461 | _tJournal of Nanobiotechnology | ||
| 463 |
_tVol. 17, iss. 1 _v[90, 34 p.] _d2020 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _anuclear medicine | |
| 610 | 1 | _adiagnostic and therapeutic radionuclides | |
| 610 | 1 | _adrug carrier systems | |
| 610 | 1 | _amonoclonal antibodies | |
| 610 | 1 | _amanoparticles | |
| 610 | 1 | _amicrospheres | |
| 610 | 1 | _aradiopharmaceuticals | |
| 610 | 1 | _atheranostics | |
| 610 | 1 | _amultimodal imaging | |
| 701 | 1 |
_aPeltek _bA. O. _gAleksey Olekseevich |
|
| 701 | 1 |
_aMuslimov _bA. R. _gAlbert Radikovich |
|
| 701 | 1 |
_aZyuzin _bM. V. _gMikhail |
|
| 701 | 1 |
_aTimin _bA. S. _cChemist _cAssociate Scientist of Tomsk Polytechnic University _f1989- _gAleksandr Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\37036 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20210322 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1186/s12951-019-0524-9 | |
| 856 | 4 | _uhttps://doi.org/10.1186/s12951-019-0558-z | |
| 856 | 4 | _uhttp://earchive.tpu.ru/handle/11683/64872 | |
| 942 | _cCF | ||