| 000 | 03340nlm1a2200553 4500 | ||
|---|---|---|---|
| 001 | 664042 | ||
| 005 | 20231030041916.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\35212 | ||
| 035 | _aRU\TPU\network\35118 | ||
| 090 | _a664042 | ||
| 100 | _a20210324a2020 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aAssociation between 8 P‐glycoprotein (MDR1/ABCB1) gene polymorphisms and antipsychotic drug‐induced hyperprolactinaemia _fL. M. Geers, I. V. Pozhidaev, S. A. Ivanova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 43 tit.] | ||
| 330 | _aHyperprolactinaemia, a common adverse effect of antipsychotic drugs, is primarily linked to blockade of dopamine D2 receptors in the pituitary gland. Certain antipsychotic drugs, such as, for example risperidone and paliperidone, are more likely to induce hyperprolactinaemia compared to others. This effect is probably caused by a relatively high blood/brain concentration ratio, a consequence of being a substrate of P‐glycoprotein. Genetic variants of P‐glycoprotein with changed functional activity might influence the potential of risperidone and paliperidone to cause hyperprolactinaemia as the altered blood/brain concentration ratio would lead to a reduced therapeutic drug level within essential brain areas making dose adaptations necessary. This increases exposure of dopamine D2 receptors within the pituitary gland. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tBritish Journal of Clinical Pharmacology | ||
| 463 |
_tVol. 86, iss. 9 _v[P. 1827-1835] _d2020 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aantipsychotics | |
| 610 | 1 | _ahyperprolactinaemia | |
| 610 | 1 | _aMDR1/ABCB1 gene | |
| 610 | 1 | _aP-glycoprotein | |
| 610 | 1 | _apolymorphisms | |
| 701 | 1 |
_aGeers _bL. M. |
|
| 701 | 1 |
_aPozhidaev _bI. V. _gIvan |
|
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 701 | 1 |
_aFreydin _bM. B. _gMaksim Borisovich |
|
| 701 | 1 |
_aSchmidt _bA. F. _gAmand |
|
| 701 | 1 |
_aCohen _bD. |
|
| 701 | 1 |
_aBoyko _bA. S. |
|
| 701 | 1 |
_aPaderina _bD. Z. _gDiana |
|
| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
|
| 701 | 1 |
_aSemke _bA. V. |
|
| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
|
| 701 | 1 |
_aWilffert _bB. _gBob |
|
| 701 | 1 |
_aKosterink _bJ. G.W. _gJos |
|
| 701 | 1 |
_aTouw _bD. J. |
|
| 701 | 1 |
_aLoonen _bA. J. M _gAnton |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа неразрушающего контроля и безопасности _bОтделение контроля и диагностики _h7978 _2stltpush _3(RuTPU)RU\TPU\col\23584 |
| 801 | 2 |
_aRU _b63413507 _c20210324 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1111/bcpt.13173 | |
| 942 | _cCF | ||