| 000 | 02945nlm1a2200433 4500 | ||
|---|---|---|---|
| 001 | 664088 | ||
| 005 | 20231030041918.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\35272 | ||
| 090 | _a664088 | ||
| 100 | _a20210326a2019 k y0engy50 ba | ||
| 101 | 0 |
_aeng _deng |
|
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_ac-Jun N-Terminal Kinases and Their Pharmacological Modulation in Ischemic and Reperfusion Brain Injury _fM. V. Shvedova, Ya. J. Anfinogenova, I. A. Schepetkin (Shchepyotkin), D. N. Atochin |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 86 tit.] | ||
| 330 | _aWe present here a review of the literature on the role of c-Jun N-terminal kinases (JNK) and their inhibitors in ischemic and reperfusion brain injuries. The functions of JNK in the signal mechanisms involved in brain damage in ischemia and reperfusion are discussed. Effects linked with inhibition of JNK with synthetic and natural compounds in experimental models of ischemia and reperfusion brain injury are described. Results from experimental studies show that JNK provide potential therapeutic targets for protecting the brain from ischemic stroke. However, the fact that JNK have numerous physiological functions prevents systematic use of nonspecific inhibitors of these kinases for therapeutic purposes. The authors conclude that this task requires a further search for selective JNK3 inhibitors. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 |
_tNeuroscience and Behavioral Physiology _d1967- |
||
| 463 |
_tVol. 48, iss. 6 _v[P. 721–728] _d2019 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _ac-Jun N-terminal kinase | |
| 610 | 1 | _aJNK inhibitor | |
| 610 | 1 | _astroke | |
| 610 | 1 | _aischemic-reperfusion injury | |
| 610 | 1 | _abrain | |
| 610 | 1 | _atherapeutic target | |
| 701 | 1 |
_aShvedova _bM. V. _gMariya Vitaljevna |
|
| 701 | 1 |
_aAnfinogenova _bYa. J. _cLinguist _cLecturer of Tomsk Polytechnic University, Doctor of medical sciences _f1970- _gYana Jonovna _2stltpush _3(RuTPU)RU\TPU\pers\33592 |
|
| 701 | 1 |
_aSchepetkin (Shchepyotkin) _bI. A. _cdoctor-biophysicist _cleading researcher of Tomsk Polytechnic University, candidate of medical science _f1962- _gIgor Aleksandrovich _2stltpush _3(RuTPU)RU\TPU\pers\37358 |
|
| 701 | 1 |
_aAtochin _bD. N. _gDmitry Nikolaevich |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа новых производственных технологий _bНаучно-образовательный центр Н. М. Кижнера _h7872 _2stltpush _3(RuTPU)RU\TPU\col\23556 |
| 801 | 2 |
_aRU _b63413507 _c20210326 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1007/s11055-018-0622-4 | |
| 942 | _cCF | ||