| 000 | 05459nlm1a2200541 4500 | ||
|---|---|---|---|
| 001 | 664198 | ||
| 005 | 20231030041921.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\35382 | ||
| 090 | _a664198 | ||
| 100 | _a20210331a2019 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aPoly(ε-caprolactone) Scaffolds Doped with c-Jun N-terminal Kinase Inhibitors Modulate Phagocyte Activation _fK. S. Stankevich, I. A. Schepetkin (Shchepyotkin), S. I. Goreninsky (Goreninskii) [et al.] |
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| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aThe modulation of phagocyte responses is essential for successful performance of biomaterials in order to prevent negative outcomes associated with inflammation. Herein, we developed electrospun poly(ε-caprolactone) (PCL) scaffolds doped with the novel potent c-Jun N-terminal kinase (JNK) inhibitors 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) and 11H-indeno[1,2-b]quinoxalin-11-one O-(O-ethylcarboxymethyl) oxime(IQ-1E) as a promising approach for modulating phagocyte activation. Optimized electrospinning parameters allowed us to produce microfiber composite materials with suitable mechanical properties. We found that embedded compounds were bound to the polymer matrix via hydrophobic interactions and released in two steps, with release mostly controlled by Fickian diffusion. The fabricated scaffolds doped with active compounds IQ-1 and IQ-1E effectively inhibited phagocyte inflammatory responses. For example, they suppressed human neutrophil activation by the biomaterials, as indicated by decreased neutrophil reactive oxygen species (ROS) production and Ca2+ mobilization. In addition, they inhibited lipopolysaccharide (LPS)-induced NF-κB/AP-1 reporter activity in THP-1Blue cells and interleukin (IL)-6 production in MonoMac-6 cells without affecting cell viability. These effects were attributed to the released compounds rather than cell-surface interactions. Therefore, our study demonstrates that doping tissue engineering scaffolds with novel JNK inhibitors represents a powerful tool for preventing adverse immune responses to biomaterials as well as serves as a platform for drug delivery. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tACS Biomaterials Science and Engineering | ||
| 463 |
_tVol. 5, iss. 11 _v[P. 5990–5999] _d2019 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _apoly(e-caprolactone) | |
| 610 | 1 | _aelectrospinning | |
| 610 | 1 | _ac-Jun-N-terminal kinase | |
| 610 | 1 | _aJNK inhibitor | |
| 610 | 1 | _aneutrophil | |
| 610 | 1 | _aimmune response | |
| 610 | 1 | _abiomaterial | |
| 701 | 1 |
_aStankevich _bK. S. _cPhysicist _cEngineer Tomsk Polytechnic University _f1992- _gKsenia Sergeevna _2stltpush _3(RuTPU)RU\TPU\pers\37546 |
|
| 701 | 1 |
_aSchepetkin (Shchepyotkin) _bI. A. _cdoctor-biophysicist _cleading researcher of Tomsk Polytechnic University, candidate of medical science _f1962- _gIgor Aleksandrovich _2stltpush _3(RuTPU)RU\TPU\pers\37358 |
|
| 701 | 1 |
_aGoreninsky (Goreninskii) _bS. I. _cchemist _cengineer of Tomsk Polytechnic University _f1993- _gSemen Igorevich _2stltpush _3(RuTPU)RU\TPU\pers\40080 |
|
| 701 | 1 |
_aLavrinenko _bA. K. _gAnastasiya Konstantinovna |
|
| 701 | 1 |
_aBolbasov _bE. N. _cphysicist _cAssociate Scientist of Tomsk Polytechnic University, Candidate of Sciences _f1981- _gEvgeny Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\30857 |
|
| 701 | 1 |
_aKovrizhina _bA. R. _cbiotechnology specialist _cResearch Engineer of Tomsk Polytechnic University _f1995- _gAnastasia Ruslanovna _2stltpush _3(RuTPU)RU\TPU\pers\46608 |
|
| 701 | 1 |
_aKirpotina _bL. N. _gLiliya Nikolaevna |
|
| 701 | 1 |
_aFilimonov _bV. D. _cRussian chemist _cProfessor of the TPU _f1945- _gViktor Dmitrievich _2stltpush _3(RuTPU)RU\TPU\pers\26423 |
|
| 701 | 1 |
_aKhlebnikov _bA. I. _cChemist _cProfessor of Tomsk Polytechnic University _f1963- _gAndrey Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\33927 |
|
| 701 | 1 |
_aTverdokhlebov _bS. I. _cphysicist _cAssociate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science _f1961- _gSergei Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\30855 |
|
| 701 | 1 |
_aQuinn _bM. T. _gMark |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа новых производственных технологий _bНаучно-образовательный центр Н. М. Кижнера _h7872 _2stltpush _3(RuTPU)RU\TPU\col\23556 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа ядерных технологий _bЛаборатория плазменных гибридных систем _h7887 _2stltpush _3(RuTPU)RU\TPU\col\23381 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа ядерных технологий _bНаучно-образовательный центр Б. П. Вейнберга _h7866 _2stltpush _3(RuTPU)RU\TPU\col\23561 |
| 801 | 2 |
_aRU _b63413507 _c20210331 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1021/acsbiomaterials.9b01401 | |
| 942 | _cCF | ||