| 000 | 03651nlm1a2200457 4500 | ||
|---|---|---|---|
| 001 | 664226 | ||
| 005 | 20231030041922.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\35410 | ||
| 035 | _aRU\TPU\network\35009 | ||
| 090 | _a664226 | ||
| 100 | _a20210401a2019 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aNuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy _fV. M. Petriev, V. K. Tishchenko, A. A. Mikhaylovskaya [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 26 tit.] | ||
| 330 | _aNuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic 188Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radioactive 188Re takes merely 1?hour, compared to its half-life of 17?hours. When intravenously administered in a Wistar rat model, the conjugates demonstrate free circulation in the blood stream to reach all organs and target tumors, which is radically in contrast with that of the 188Re salt that mostly accumulates in the thyroid gland. We also show that the nanoparticles ensure excellent retention of 188Re in tumor, not possible with the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-delayed conjugate bioelimination. Finally, our tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the control group). Combined with a series of imaging and therapeutic functionalities based on unique intrinsic properties of Si nanoparticles, the proposed biodegradable complex promises a major advancement in nuclear nanomedicine. | ||
| 461 | _tScientific Reports | ||
| 463 |
_tVol. 9 _v[2017, 10 p.] _d2019 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aPetriev _bV. M. _gVasily Mikhaylovich |
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| 701 | 1 |
_aTishchenko _bV. K. |
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| 701 | 1 |
_aMikhaylovskaya _bA. A. _gAnastasiya Aleksandrovna |
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| 701 | 1 |
_aPopov _bA. A. |
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| 701 | 1 |
_aTselikov _bG. _gGleb |
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| 701 | 1 |
_aZelepukin _bI. V. _gIvan Vladimirovich |
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| 701 | 1 |
_aDeev _bS. M. _cbiologist _cLeading Researcher, Tomsk Polytechnic University, Doctor of Biological Sciences _f1951- _gSergey Mikhaylovich _2stltpush _3(RuTPU)RU\TPU\pers\39299 |
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| 701 | 1 |
_aKaprin _bA. D. _gAndrey Dmitrievich |
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| 701 | 1 |
_aIvanov _bS. |
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| 701 | 1 |
_aTimoshenko _bV. Yu. _gViktor Yurjevich |
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| 701 | 1 |
_aPrasad _bP. N. |
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| 701 | 1 |
_aZavestovskaya _bN. I. _gNina Iljinichna |
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| 701 | 1 |
_aKabashin _bA. V. _gAndrey Viktorovich |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bФизико-технический институт _bЛаборатория № 31 ядерного реактора _h6471 _2stltpush _3(RuTPU)RU\TPU\col\20054 |
| 801 | 2 |
_aRU _b63413507 _c20210401 _gRCR |
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| 856 | 4 | _uhttps://doi.org/10.1038/s41598-018-38474-7 | |
| 942 | _cCF | ||