| 000 | 03307nlm1a2200481 4500 | ||
|---|---|---|---|
| 001 | 664301 | ||
| 005 | 20231030041925.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\35485 | ||
| 035 | _aRU\TPU\network\31193 | ||
| 090 | _a664301 | ||
| 100 | _a20210407a2019 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aPolysaccharides based microspheres for multiple encapsulations and simultaneous release of proteases _fK. Ozaltin, P. S. Postnikov, M. E. Trusova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 34 tit.] | ||
| 330 | _aThe work is focused on the development of microspheres based on the combination of two polysaccharides; chitosan and alginic acid with the aim to allocate, hold, release and protect environmentally sensible molecules. The microspheres were prepared using a solvent-free, low cost and scalable approach and two enzymes; trypsin and protease from Aspergillus Oryzae have been used as a model to evaluate the microspheres peculiarities. The proteins were encapsulated during the microspheres preparation. The relationship between the polysaccharides weight ratio and the morphology, stability and ability of the carrier to allocate the enzymes has been evaluated. The enzymatic activity and the release kinetics were assessed in different conditions to assess the impact of the external environment. Obtained results demonstrate the efficacy of the prepared microspheres to preserve the activity of relevant bioactive compounds which are highly relevant in food, cosmetic and pharmaceutic, but the application is limited due to their high sensibility. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tInternational Journal of Biological Macromolecules | ||
| 463 |
_tVol. 132 _v[P. 24-31] _d2019 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _amicroencapsulation | |
| 610 | 1 | _amicrospheres | |
| 610 | 1 | _apolysaccharides | |
| 610 | 1 | _aprotease | |
| 610 | 1 | _acontrolled delivery | |
| 610 | 1 | _aмикрокапсулирование | |
| 610 | 1 | _aмикросферы | |
| 610 | 1 | _aполисахариды | |
| 610 | 1 | _aбиоактивные соединения | |
| 701 | 1 |
_aOzaltin _bK. _gKadir |
|
| 701 | 1 |
_aPostnikov _bP. S. _corganic chemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1984- _gPavel Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\31287 |
|
| 701 | 1 |
_aTrusova _bM. E. _corganic chemist _cAssociate professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1982- _gMarina Evgenievna _2stltpush _3(RuTPU)RU\TPU\pers\31823 |
|
| 701 | 1 |
_aSedlarik _bV. _gVladimir |
|
| 701 | 1 |
_aDi _bM. A. _gMartino Antonio |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20210407 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.ijbiomac.2019.03.189 | |
| 942 | _cCF | ||