| 000 | 03910nlm1a2200529 4500 | ||
|---|---|---|---|
| 001 | 664930 | ||
| 005 | 20231030041946.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\36115 | ||
| 035 | _aRU\TPU\network\35468 | ||
| 090 | _a664930 | ||
| 100 | _a20210601a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aCH | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aOximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential _fI. A. Schepetkin (Shchepyotkin), M. B. Plotnikov, A. I. Khlebnikov [et al.] |
|
| 203 |
_aText _celectronic |
||
| 320 | _a[References: 217 tit.] | ||
| 330 | _aOximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with antibacterial, anticancer, anti-arthritis, and anti-stroke activities. Many oximes are kinase inhibitors and have been shown to inhibit over 40 different kinases, including AMP-activated protein kinase (AMPK), phosphatidylinositol 3-kinase (PI3K), cyclin-dependent kinase (CDK), serine/threonine kinases glycogen synthase kinase 3 a/Я (GSK-3a/Я), Aurora A, B-Raf, Chk1, death-associated protein-kinase-related 2 (DRAK2), phosphorylase kinase (PhK), serum and glucocorticoid-regulated kinase (SGK), Janus tyrosine kinase (JAK), and multiple receptor and non-receptor tyrosine kinases. Some oximes are inhibitors of lipoxygenase 5, human neutrophil elastase, and proteinase 3. The oxime group contains two H-bond acceptors (nitrogen and oxygen atoms) and one H-bond donor (OH group), versus only one H-bond acceptor present in carbonyl groups. This feature, together with the high polarity of oxime groups, may lead to a significantly different mode of interaction with receptor binding sites compared to corresponding carbonyl compounds, despite small changes in the total size and shape of the compound. In addition, oximes can generate nitric oxide. This review is focused on oximes as kinase inhibitors with anticancer and anti-inflammatory activities. Oximes with non-kinase targets or mechanisms of anti-inflammatory activity are also discussed. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tBiomolecules | ||
| 463 |
_tVol. 11, iss. 6 _v[777, 33 p.] _d2021 |
||
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aoxime | |
| 610 | 1 | _akinase inhibitor | |
| 610 | 1 | _aindirubin | |
| 610 | 1 | _anitric oxide | |
| 610 | 1 | _amolecular modeling | |
| 610 | 1 | _ainflammation | |
| 610 | 1 | _acancer | |
| 610 | 1 | _aоксимы | |
| 610 | 1 | _aингибиторы | |
| 610 | 1 | _aоксид азота | |
| 610 | 1 | _aмолекулярное моделирование | |
| 610 | 1 | _aвоспаление | |
| 610 | 1 | _aрак | |
| 701 | 1 |
_aSchepetkin (Shchepyotkin) _bI. A. _cdoctor-biophysicist _cleading researcher of Tomsk Polytechnic University, candidate of medical science _f1962- _gIgor Aleksandrovich _2stltpush _3(RuTPU)RU\TPU\pers\37358 |
|
| 701 | 1 |
_aPlotnikov _bM. B. _gMark Borisovich |
|
| 701 | 1 |
_aKhlebnikov _bA. I. _cChemist _cProfessor of Tomsk Polytechnic University _f1963- _gAndrey Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\33927 |
|
| 701 | 1 |
_aPlotnikova _bT. M. _gTatjyana Makarovna |
|
| 701 | 1 |
_aQuinn _bM. T. _gMark |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа новых производственных технологий _bНаучно-образовательный центр Н. М. Кижнера _h7872 _2stltpush _3(RuTPU)RU\TPU\col\23556 |
| 801 | 2 |
_aRU _b63413507 _c20210601 _gRCR |
|
| 856 | 4 | 0 | _uhttps://doi.org/10.3390/biom11060777 |
| 942 | _cCF | ||