| 000 | 04272nlm1a2200577 4500 | ||
|---|---|---|---|
| 001 | 665223 | ||
| 005 | 20231030041956.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\36422 | ||
| 035 | _aRU\TPU\network\35273 | ||
| 090 | _a665223 | ||
| 100 | _a20210903a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aNL | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aA genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesia _fA. S. Levchenko, A. Kanapin, Samsonova A. I. Samsonova [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 330 | _aIn the present study we conducted a genome-wide association study (GWAS) in a cohort of 505 patients with paranoid schizophrenia (SCZ), of which 95 had tardive dyskinesia (TD), and 503 healthy controls. Using data generated by the PsychENCODE Consortium (PEC) and other bioinformatic databases, we revealed a gene network, implicated in neurodevelopment and brain function, associated with both these disorders. Almost all these genes are in gene or isoform co-expression PEC network modules important for the functioning of the brain; the activity of these networks is also altered in SCZ, bipolar disorder and autism spectrum disorders. The associated PEC network modules are enriched for gene ontology terms relevant to the brain development and function (CNS development, neuron development, axon ensheathment, synapse, synaptic vesicle cycle, and signaling receptor activity) and to the immune system (inflammatory response). | ||
| 330 | _aResults of the present study suggest that orofacial and limbtruncal types of TD seem to share the molecular network with SCZ. Paranoid SCZ and abnormal involuntary movements that indicate the orofacial type of TD are associated with the same genomic loci on chromosomes 3p22.2, 8q21.13, and 13q14.2. The limbtruncal type of TD is associated with a locus on chromosome 3p13 where the best functional candidate is FOXP1, a high-confidence SCZ gene. The results of this study shed light on common pathogenic mechanisms for SCZ and TD, and indicate that the pathogenesis of the orofacial and limbtruncal types of TD might be driven by interacting genes implicated in neurodevelopment. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tProgress in Neuro-Psychopharmacology and Biological Psychiatry | ||
| 463 |
_tVol. 105 _v[110134, 12 p.] _d2021 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aschizophrenia | |
| 610 | 1 | _atardive dyskinesia | |
| 610 | 1 | _aGWAS | |
| 610 | 1 | _agene networks | |
| 610 | 1 | _aregulatory sequence | |
| 610 | 1 | _aшизофрения | |
| 610 | 1 | _aгенные сети | |
| 610 | 1 | _aнервная система | |
| 610 | 1 | _aбиполярное расстройство | |
| 701 | 1 |
_aLevchenko _bA. S. _gAnastasiya Sergeevna |
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| 701 | 1 |
_aKanapin _bA. |
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| 701 | 1 |
_aSamsonova _bSamsonova A. I. _gAnastasiya Igorevna |
|
| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
|
| 701 | 1 |
_aKornetova _bE. G. _gElena Georgievna |
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| 701 | 1 |
_aNurgaliev _bT. |
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| 701 | 1 |
_aMazo _bG. E. |
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| 701 | 1 |
_aSemke _bA. V. _gArkady Valentinovich |
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| 701 | 1 |
_aKibitov _bA. O. |
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| 701 | 1 |
_aBokhan _bN. |
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| 701 | 1 |
_aGainetdinov _bR. R. |
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| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа неразрушающего контроля и безопасности _bОтделение контроля и диагностики _h7978 _2stltpush _3(RuTPU)RU\TPU\col\23584 |
| 801 | 2 |
_aRU _b63413507 _c20210903 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.pnpbp.2020.110134 | |
| 942 | _cCF | ||