| 000 | 03511nlm1a2200445 4500 | ||
|---|---|---|---|
| 001 | 665423 | ||
| 005 | 20231030042002.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\36622 | ||
| 035 | _aRU\TPU\network\35459 | ||
| 090 | _a665423 | ||
| 100 | _a20210925a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aEvaluation of silver nanoparticles for the prevention of SARS-CoV-2 infection in health workers: In vitro and in vivo _fH. Almanza, S. Moreno, I. Plascencia-Lopez [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 36 tit.] | ||
| 330 | _aSARS-CoV-2 infection in hospital areas is of a particular concern, since the close interaction between health care personnel and patients diagnosed with COVID-19, which allows virus to be easily spread between them and subsequently to their families and communities. Preventing SARS-CoV-2 infection among healthcare personnel is essential to reduce the frequency of infections and outbreaks during the pandemic considering that they work in high-risk areas. In this research, silver nanoparticles (AgNPs) were tested in vitro and shown to have an inhibitory effect on SARS-CoV-2 infection in cultured cells. Subsequently, we assess the effects of mouthwash and nose rinse with ARGOVIT® silver nanoparticles (AgNPs), in the prevention of SARS-CoV-2 contagion in health workers consider as high-risk group of acquiring the infection in the General Tijuana Hospital, Mexico, a hospital for the exclusive recruitment of patients diagnosed with COVID-19. We present a prospective randomized study of 231 participants that was carried out for 9 weeks (during the declaration of a pandemic). The "experimental" group was instructed to do mouthwash and nose rinse with the AgNPs solution; the "control" group was instructed to do mouthwashes and nose rinse in a conventional way. The incidence of SARS-CoV-2 infection was significantly lower in the "experimental" group (two participants of 114, 1.8%) compared to the "control" group (thirty-three participants of 117, 28.2%), with an 84.8% efficiency. We conclude that the mouth and nasal rinse with AgNPs helps in the prevention of SARS-CoV-2 infection in health personnel who are exposed to patients diagnosed with COVID-19. | ||
| 461 | _tPLoS One | ||
| 463 |
_tVol. 16, iss. 8 _v[e0256401, 14 p.] _d2021 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aAlmanza _bH. _gHoracio |
|
| 701 | 1 |
_aMoreno _bS. _gSandra |
|
| 701 | 1 |
_aPlascencia-Lopez _bI. _gIsmael |
|
| 701 | 1 |
_aAlvarado-Vera _bM. _gMartha |
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| 701 | 1 |
_aPatron-Romero _bL. _gLeslie |
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| 701 | 1 |
_aBorrego _bB. _gBelen |
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| 701 | 1 |
_aReyes-Escamilla _bA. _gAlberto |
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| 701 | 1 |
_aValencia-Manzo _bD. _gDaniel |
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| 701 | 1 |
_aBrun _bA. _gAlejandro |
|
| 701 | 1 |
_aPestryakov _bA. N. _cChemist _cProfessor of Tomsk Polytechnic University, Doctor of Chemical Science _f1963- _gAleksey Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\30471 |
|
| 701 | 1 |
_aBogdanchikova _bN. _gNina |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20210925 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1371/journal.pone.0256401 | |
| 942 | _cCF | ||