| 000 | 03277nlm1a2200553 4500 | ||
|---|---|---|---|
| 001 | 666212 | ||
| 005 | 20231030042029.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\37416 | ||
| 035 | _aRU\TPU\network\37303 | ||
| 090 | _a666212 | ||
| 100 | _a20211210a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aMolecular Mechanisms for Regulation of Neutrophil Apoptosis under Normal and Pathological Conditions _fE. M. Noseykina, I. A. Schepetkin (Shchepyotkin), D. N. Atochin |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 149 tit.] | ||
| 330 | _aNeutrophils are one of the main cells of innate immunity that perform a key effector and regulatory function in the development of the human inflammatory response. Apoptotic forms of neutrophils are important for regulating the intensity of inflammation and restoring tissue homeostasis. This review summarizes current data on the molecular mechanisms of modulation of neutrophil apoptosis by the main regulatory factors of the inflammatory response-cytokines, integrins, and structural components of bacteria. Disturbances in neutrophil apoptosis under stress are also considered, molecular markers of changes in neutrophil lifespan associated with various diseases and pathological conditions are presented, and data on pharmacological agents for modulating apoptosis as potential therapeutics are also discussed. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 338 |
_bРоссийский научный фонд _d17-15-01111 |
||
| 461 | _tJournal of Evolutionary Biochemistry and Physiology | ||
| 463 |
_tVol. 57, iss. 3 _v[P. 429-450] _d2021 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aneutrophils | |
| 610 | 1 | _aapoptosis | |
| 610 | 1 | _ainflammation | |
| 610 | 1 | _astress | |
| 610 | 1 | _ainnate immunity | |
| 610 | 1 | _acytokines | |
| 610 | 1 | _acell life span | |
| 610 | 1 | _aнейтрофилы | |
| 610 | 1 | _aапоптоз | |
| 610 | 1 | _aвоспаление | |
| 610 | 1 | _aстрессы | |
| 610 | 1 | _aиммунитеты | |
| 610 | 1 | _aцитокины | |
| 610 | 1 | _aпродолжительность | |
| 610 | 1 | _aклетки | |
| 700 | 1 |
_aNoseykina _bE. M. _gElena Mikhaylovna |
|
| 701 | 1 |
_aSchepetkin (Shchepyotkin) _bI. A. _cdoctor-biophysicist _cleading researcher of Tomsk Polytechnic University, candidate of medical science _f1962- _gIgor Aleksandrovich _2stltpush _3(RuTPU)RU\TPU\pers\37358 |
|
| 701 | 1 |
_aAtochin _bD. N. _cneuroscientist _cThe Head of the Laboratory of Tomsk Polytechnic University _f1960- _gDmitry Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\37514 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа новых производственных технологий _bНаучно-образовательный центр Н. М. Кижнера _h7872 _2stltpush _3(RuTPU)RU\TPU\col\23556 |
| 801 | 2 |
_aRU _b63413507 _c20211210 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1134/S0022093021030017 | |
| 942 | _cCF | ||