| 000 | 03811nlm1a2200625 4500 | ||
|---|---|---|---|
| 001 | 666370 | ||
| 005 | 20231030042034.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\37574 | ||
| 035 | _aRU\TPU\network\37573 | ||
| 090 | _a666370 | ||
| 100 | _a20211220a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aCH | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aChemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques _fAk. Shamil, S. A. Afanasjev, M. E. Trusova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 33 tit.] | ||
| 330 | _aAtherosclerosis, a systematic degenerative disease related to the buildup of plaques in human vessels, remains the major cause of morbidity in the field of cardiovascular health problems, which are the number one cause of death globally. Novel atheroprotective HDL-mimicking chemically modified carbon-coated iron nanoparticles (Fe@C NPs) were produced by gas-phase synthesis and modified with organic functional groups of a lipophilic nature. Modified and non-modified Fe@C NPs, immobilized with polycaprolactone on stainless steel, showed high cytocompatibility in human endothelial cell culture. Furthermore, after ex vivo treatment of native atherosclerotic plaques obtained during open carotid endarterectomy surgery, Fe@C NPs penetrated the inner structures and caused structural changes of atherosclerotic plaques, depending on the period of implantation in Wistar rats, serving as a natural bioreactor. The high biocompatibility of the Fe@C NPs shows great potential in the treatment of atherosclerosis disease as an active substance of stent coatings to prevent restenosis and the formation of atherosclerotic plaques. | ||
| 461 | _tBiomedicines | ||
| 463 |
_tVol. 9, iss. 7 _v[802, 15 p.] _d2021 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aatherosclerosis | |
| 610 | 1 | _ahigh density lipoprotein | |
| 610 | 1 | _achemically modified carbon-coated iron nanoparticle | |
| 610 | 1 | _areverse cholesterol transport | |
| 610 | 1 | _amacrophage | |
| 610 | 1 | _acoronary stent | |
| 610 | 1 | _aатеросклероз | |
| 610 | 1 | _aнаночастицы | |
| 610 | 1 | _aжелезо | |
| 610 | 1 | _aхолестерин | |
| 610 | 1 | _aуглеродные покрытия | |
| 610 | 1 | _aстенты | |
| 701 | 1 |
_aShamil _bAk. _gAkhmedov |
|
| 701 | 1 |
_aAfanasjev _bS. A. _gSergey Aleksandrovich |
|
| 701 | 1 |
_aTrusova _bM. E. _corganic chemist _cAssociate professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1982- _gMarina Evgenievna _2stltpush _3(RuTPU)RU\TPU\pers\31823 |
|
| 701 | 1 |
_aPostnikov _bP. S. _corganic chemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1984- _gPavel Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\31287 |
|
| 701 | 1 |
_aRogovskaya _bYu. V. _gYuliya Viktorovna |
|
| 701 | 1 |
_aGrakova _bE. V. _gElena Viktorovna |
|
| 701 | 1 |
_aKopeva _bK. _gKristina |
|
| 701 | 1 |
_aPaz _bR. C. _gRosa Carreon |
|
| 701 | 1 |
_aBalakin _bS. _gSascha |
|
| 701 | 1 |
_aWiesmann _bH. P. _gHans Peter |
|
| 701 | 1 |
_aJorg _bO. _gOpitz |
|
| 701 | 1 |
_aKruppke _bB. _gBenjamin |
|
| 701 | 1 |
_aBeshchasna _bN. _gNatalia |
|
| 701 | 1 |
_aPopov _bS. V. _gSergey |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20211220 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.3390/biomedicines9070802 | |
| 942 | _cCF | ||