| 000 | 03389nlm1a2200529 4500 | ||
|---|---|---|---|
| 001 | 666406 | ||
| 005 | 20231030042036.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\37610 | ||
| 035 | _aRU\TPU\network\37603 | ||
| 090 | _a666406 | ||
| 100 | _a20211223a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrgn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aPreliminary Pharmacogenetic Study to Explore Putative Dopaminergic Mechanisms of Antidepressant Action _fT. Ochi, N. M. Vyalova, I. S. Losenkov [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 37 tit.] | ||
| 330 | _aBackground: There is sufficient evidence that interference of dopaminergic neurotransmission contributes to the therapeutic effects of antidepressants in unipolar and bipolar depression. Methods: Hamilton depression rating scale (HAMD 17) scores of 163 at least moderately ill patients with major depressive disorders were used to establish treatment response. HAMD 17 score status was measured before initiation, after two weeks, and after four weeks of treatment with various antidepressants. The possible association between response and genotype in a total of 14 variants of dopamine neurotransmission-related proteins was investigated. Results: DRD4 rs11246226 CA heterozygous patients were found with a greater improvement of HAMD 17 score when compared to homozygous C patients during 0-2 weeks and 0-4 weeks. Patients with MAOB rs1799836 heterozygous GA and homozygous A also demonstrated improved scores during 2-4 weeks and 0-4 weeks. Conclusions: The results are preliminary due to the limited population size and the small number of variants. Further research into the involvement of habenular dopamine D4 receptors in the antidepressant response is desirable. | ||
| 461 | _tJournal of Personalized Medicine | ||
| 463 |
_tVol. 11, iss. 8 _v[731, 8 p.] _d2021 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _adopaminergic pathway | |
| 610 | 1 | _adepression | |
| 610 | 1 | _aantidepressants | |
| 610 | 1 | _amood disorders | |
| 610 | 1 | _adopamine | |
| 610 | 1 | _apharmacogenetics | |
| 610 | 1 | _aдепрессия | |
| 610 | 1 | _aантидепрессанты | |
| 610 | 1 | _aрасстройства | |
| 701 | 1 |
_aOchi _bT. _gTaichi |
|
| 701 | 1 |
_aVyalova _bN. M. _gNataljya Mikhaylovna |
|
| 701 | 1 |
_aLosenkov _bI. S. _gInnokenty Sergeevich |
|
| 701 | 1 |
_aPaderina _bD. Z. _gDiana |
|
| 701 | 1 |
_aPozhidaev _bI. V. _gIvan Vyacheslavovich |
|
| 701 | 1 |
_aLoonen _bA. J. M. _gAnton |
|
| 701 | 1 |
_aSimutkin _bG. G. _gGerman Gennadjevich |
|
| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
|
| 701 | 1 |
_aWilffert _bB. _gBob |
|
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа неразрушающего контроля и безопасности _bОтделение контроля и диагностики _h7978 _2stltpush _3(RuTPU)RU\TPU\col\23584 |
| 801 | 2 |
_aRU _b63413507 _c20211223 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.3390/jpm11080731 | |
| 942 | _cCF | ||