| 000 | 03728nlm1a2200517 4500 | ||
|---|---|---|---|
| 001 | 666740 | ||
| 005 | 20231030042047.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\37944 | ||
| 035 | _aRU\TPU\network\26598 | ||
| 090 | _a666740 | ||
| 100 | _a20220124a2018 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aPMIDA-Modified Fe3O4 Magnetic Nanoparticles: Synthesis and Application for Liver MRI _fA. M. Demin, A. G. Pershina, A. S. Minin [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 55 tit.] | ||
| 330 | _aThe surface modification of Fe3O4-based magnetic nanoparticles (MNPs) with N-(phosphonomethyl)iminodiacetic acid (PMIDA) was studied, and the possibility of their use as magnetic resonance imaging contrast agents was shown. The effect of the added PMIDA amount, the reaction temperature and time on the degree of immobilization of this reagent on MNPs, and the hydrodynamic characteristics of their aqueous colloidal solutions have been systematically investigated for the first time. It has been shown that the optimum condition for the modification of MNPs is the reaction at 40 °C with an equimolar amount of PMIDA for 3.5 h. The modified MNPs were characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric, and CHN elemental analyses. The dependence of the hydrodynamic characteristics of the MNP colloidal solutions on the concentration and pH of the medium was studied by the dynamic light scattering method. On the basis of the obtained data, we can assume that the PMIDA molecules are fixed on the surface of the MNPs as a monomolecular layer. The modified MNPs had good colloidal stability and high magnetic properties. The calculated relaxivities r2 and r1 were 341 and 102 mmol-1 s-1, respectively. The possibility of using colloidal solutions of PMIDA-modified MNPs as a T2 contrast agent for liver studies in vivo (at a dose of 0.6 mg kg-1) was demonstrated for the first time. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tLangmuir | ||
| 463 |
_tVol. 34, iss. 11 _v[P. 3449-3458] _d2018 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aмагнитные наночастицы | |
| 610 | 1 | _aмагнитно-резонансная томография | |
| 610 | 1 | _aколлоидные растворы | |
| 610 | 1 | _aсветорассеяние | |
| 610 | 1 | _aконтрастные средства | |
| 701 | 1 |
_aDemin _bA. M. _gAleksandr Mikhaylovich |
|
| 701 | 1 |
_aPershina _bA. G. _cbiologist _cAssociate Professor of Tomsk Polytechnic University, Candidate of biological sciences _f1981- _gAleksandra Gennadievna _2stltpush _3(RuTPU)RU\TPU\pers\32466 |
|
| 701 | 1 |
_aMinin _bA. S. _gArtem |
|
| 701 | 1 |
_aMekhaev _bA. V. _gAlexander |
|
| 701 | 1 |
_aIvanov _bV. V. _gVladimir |
|
| 701 | 1 |
_aLezhava _bS. P. _gSofiya |
|
| 701 | 1 |
_aZakharova _bA. A. _gAlexandra |
|
| 701 | 1 |
_aByzov _bI. V. _gIliya |
|
| 701 | 1 |
_aUimin _bM. A. _gMikhail |
|
| 701 | 1 |
_aKrasnov _bV. P. _gVictor |
|
| 701 | 1 |
_aOgorodova _bL. M. _gLudmila |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20230517 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1021/acs.langmuir.7b04023 | |
| 942 | _cCF | ||