| 000 | 03851nlm1a2200541 4500 | ||
|---|---|---|---|
| 001 | 667062 | ||
| 005 | 20231030042058.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\38266 | ||
| 035 | _aRU\TPU\network\15786 | ||
| 090 | _a667062 | ||
| 100 | _a20220218a2017 k y0rusy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrgn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aAssociation of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders _fV. A. Toshchakova, Y. Bakhtiari, A. V. Kulikov [et al.] |
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| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 73 tit.] | ||
| 330 | _aBackground: Human aggression is a heterogeneous behavior with biological, psychological, and social backgrounds. As the biological mechanisms that regulate aggression are components of both reward-seeking and adversity-fleeing behavior, these phenomena are difficult to disentangle into separate neurochemical processes. Nevertheless, evidence exists linking some forms of aggression to aberrant serotonergic neurotransmission. We determined possible associations between 6 serotonergic neurotransmission-related gene variants and severe criminal offenses. Methods: Male Russian prisoners who were convicted for murder (n = 117) or theft (n = 77) were genotyped for variants of the serotonin transporter (5HTTLPR), tryptophan hydroxylase, tryptophan-2,3-dioxygenase, or type 2C (5-HT2C) receptor genes and compared with general-population male controls (n = 161). Prisoners were psychologically phenotyped using the Buss-Durkee Hostility Inventory and the Beck Depression Inventory. Results: No differences were found between murderers and thieves either concerning genotypes or concerning psychological measures. Comparison of polymorphism distribution between groups of prisoners and controls revealed highly significant associations of 5HTTLPR and 5-HTR2C (rs6318) gene polymorphisms with being convicted for criminal behavior. Conclusions: The lack of biological differences between the 2 groups of prisoners indicates that the studied 5HT-related genes do not differentiate between the types of crimes committed. | ||
| 461 | _tNeuropsychobiology | ||
| 463 |
_tVol. 75, iss. 4 _v[P. 200-210] _d2017 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aaggression | |
| 610 | 1 | _aserotonin transporter | |
| 610 | 1 | _a5-HT2C receptor | |
| 610 | 1 | _agenotype | |
| 610 | 1 | _aгенотипы | |
| 610 | 1 | _aполиморфизм | |
| 610 | 1 | _aсеротонины | |
| 701 | 1 |
_aToshchakova _bV. A. |
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| 701 | 1 |
_aBakhtiari _bY. |
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| 701 | 1 |
_aKulikov _bA. V. |
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| 701 | 1 |
_aGusev _bS. I. |
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| 701 | 1 |
_aTrofimova _bM. V. |
|
| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
|
| 701 | 1 |
_aMikhalitskaya _bE. V. |
|
| 701 | 1 |
_aPopova _bN. K. |
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| 701 | 1 |
_aBokhan _bN. A. |
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| 701 | 1 |
_aHovens _bJ. E. |
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| 701 | 1 |
_aLoonen _bA. J. M. |
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| 701 | 1 |
_aWilffert _bB. |
|
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bЛаборатория радиационного контроля № 31 (Лаборатория РК № 31) _h6472 _2stltpush _3(RuTPU)RU\TPU\col\19161 |
| 801 | 2 |
_aRU _b63413507 _c20220218 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1159/000487484 | |
| 942 | _cCF | ||