| 000 | 04446nlm1a2200541 4500 | ||
|---|---|---|---|
| 001 | 667140 | ||
| 005 | 20231030042101.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\38345 | ||
| 035 | _aRU\TPU\network\38343 | ||
| 090 | _a667140 | ||
| 100 | _a20220225a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aDried blood spot analysis for therapeutic drug monitoring of Clozapine _fL. M. Geers, D. Cohen, L. M. Wehkamp [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 330 | _aBACKGROUND: Schizophrenia is a psychiatric disorder that affects approximately 0.4%-1% of the population worldwide. Diagnosis of schizophrenia is based primarily on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria. Clozapine is an antipsychotic drug that is mainly used in the treatment of schizophrenia patients who are refractory or intolerant to at least 2 other antipsychotics. Due to the high variability in pharmacokinetics of clozapine, therapeutic drug monitoring (TDM) is highly recommended for clozapine therapy. OBJECTIVE:To develop and clinically validate a novel sampling method using dried blood spot (DBS) to support TDM of clozapine and norclozapine. METHODS:From June 2014 to September 2014, 15 schizophrenia patients (18-55 years) treated with clozapine were included. Plasma, DBS samples made from venous samples (VDBS), and finger prick DBS (DBS) samples were obtained before administration and 2, 4, 6, and 8 hours after clozapine intake. | ||
| 330 | _aThe study was repeated in 6 Russian patients for external validation. Passing-Bablok regression and Bland-Altman analysis were used to compare the DBS, VDBS, and plasma results for clozapine and norclozapine. RESULTS:The DBS validation results showed good linearity over the concentration time curve measured for clozapine and norclozapine. The accuracy and between- and within-day precision variation values were within accepted ranges. Different blood spot volumes and hematocrit values had no significant influence on the results. The DBS samples were stable at 20°C and 37°C for 2 weeks and at -20°C for 2 years. The mean clozapine and norclozapine DBS/plasma ratios were, respectively, 0.80 (95% CI, 0.76 to 0.85) and 1.063 (95% CI, 1.027 to 1.099) in Dutch patients. The mean clozapine DBS/DPS ratio in Russian patients was 0.70 (95% CI, 0.64 to 0.76). CONCLUSION:DBS analysis is a reliable tool for blood sampling and performing TDM of clozapine and norclozapine in daily practice and substantially extends the opportunities for TDM of clozapine. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tThe Journal of Clinical Psychiatry | ||
| 463 |
_tVol. 78, iss. 9 _v[P. 1211-1218] _d2017 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aкровь | |
| 610 | 1 | _aмониторинг | |
| 610 | 1 | _aпсихические расстройства | |
| 610 | 1 | _aшизофрения | |
| 610 | 1 | _aдиагностика | |
| 610 | 1 | _aантипсихотические препараты | |
| 701 | 1 |
_aGeers _bL. M. |
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| 701 | 1 |
_aCohen _bD. |
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| 701 | 1 |
_aWehkamp _bL. M. |
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| 701 | 1 |
_avan Hateren _bK. |
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| 701 | 1 |
_aKoster _bR. A. |
|
| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
|
| 701 | 1 |
_aSemke _bA. V. |
|
| 701 | 1 |
_aBokhan _bN. |
|
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 701 | 1 |
_aKosterink _bJ. G. W. _gJos |
|
| 701 | 1 |
_aLoonen _bA. J. M. _gAnton |
|
| 701 | 1 |
_aTouw _bD. J. |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа неразрушающего контроля и безопасности _bОтделение контроля и диагностики _h7978 _2stltpush _3(RuTPU)RU\TPU\col\23584 |
| 801 | 2 |
_aRU _b63413507 _c20220225 _gRCR |
|
| 856 | 4 | _uhttp://doi.org/10.4088/jcp.16m11164 | |
| 942 | _cCF | ||