| 000 | 03973nlm1a2200649 4500 | ||
|---|---|---|---|
| 001 | 667423 | ||
| 005 | 20231030042111.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\38628 | ||
| 035 | _aRU\TPU\network\38626 | ||
| 090 | _a667423 | ||
| 100 | _a20220322a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aCH | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aThe Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route _fE. Nefedova, V. Koptev, A. S. Bobikova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 47 tit.] | ||
| 330 | _aInfectious bronchitis (IB) of chickens is a highly contagious disease characterized by damage of the respiratory system and reproductive organs in young animals caused by a virus of the genus Gamma coronavirus. The condition of the respiratory system caused by the IB virus in chickens has many similarities with the pathology of the respiratory system caused by SARS-CoV-2 in humans. The effectiveness of virucidal drugs (Argovit, Triviron, Ecocid, and lauric acid monoglyceride) was tested on chickens inoculated with a tenfold dose of a vaccine strain based on the attenuated virus H120 against IB of chickens. On the 6th day after inoculation, inflammatory changes in the intestines, lungs, and thymus were observed in the control group. The experimental groups were characterized by less pronounced inflammatory reactions and a lower proportion of thymus and lung probes containing genomic IB virus RNA. Since the virucidal activity of four orally administrated formulations was possible only in the intestine, the experimental data indirectly confirmed the hypothesis of the possibility of the predominant accumulation of coronaviruses in the intestine and subsequent lung damage due to the hematogenous redistribution of viral particles and IBV antigens. It was suggested that other coronaviruses including SARS-CoV-2 can implement a similar mechanism. | ||
| 338 |
_bРоссийский фонд фундаментальных исследований _d20-416-540006 |
||
| 461 | _tVeterinary Sciences | ||
| 463 |
_tVol. 8, iss. 10 _v[239, 14 p.] _d2021 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _avirucidal drugs | |
| 610 | 1 | _aIBV | |
| 610 | 1 | _achickens | |
| 610 | 1 | _aCoronaviridae | |
| 610 | 1 | _asilver nanoparticles | |
| 610 | 1 | _aartificial ribonuclease | |
| 610 | 1 | _amonoglyceride lauryl acid | |
| 610 | 1 | _aкоронавирусная инфекция | |
| 610 | 1 | _aнаночастицы | |
| 610 | 1 | _aсеребро | |
| 610 | 1 | _aрибонуклеазы | |
| 610 | 1 | _aинфекционные заболевания | |
| 610 | 1 | _aдыхательная система | |
| 701 | 1 |
_aNefedova _bE. _gEkaterina |
|
| 701 | 1 |
_aKoptev _bV. _gVyacheslav |
|
| 701 | 1 |
_aBobikova _bA. S. _gAnna |
|
| 701 | 1 |
_aCherepushkina _bV. _gViktoriya |
|
| 701 | 1 |
_aMironova _bT. E. _gTatjyana Evgenjevna |
|
| 701 | 1 |
_aAfonyushkin _bV. _gVasily |
|
| 701 | 1 |
_aShkil _bN. _gNikolay |
|
| 701 | 1 |
_aDonchenko _bN. _gNikolay |
|
| 701 | 1 |
_aKozlova _bYu. N. _gYuliya Nikolaevna |
|
| 701 | 1 |
_aSigareva _bN. _gNataljya |
|
| 701 | 1 |
_aDavydova _bN. _gNataljya |
|
| 701 | 1 |
_aBogdanchikova _bN. _gNina |
|
| 701 | 1 |
_aPestryakov _bA. N. _cChemist _cProfessor of Tomsk Polytechnic University, Doctor of Chemical Science _f1963- _gAleksey Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\30471 |
|
| 701 | 1 |
_aToledano-Magana _bYa. _gYanis |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20220322 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.3390/vetsci8100239 | |
| 942 | _cCF | ||