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| 001 | 667664 | ||
| 005 | 20231030042121.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\38875 | ||
| 035 | _aRU\TPU\network\38712 | ||
| 090 | _a667664 | ||
| 100 | _a20220411a2021 k y0rusy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aNovel and validated non-aqueous titrimetric method for determination of perspective potassium-sparing diuretic drug candidate in pure form and pharmaceutical formulation _fA. A. Ivanov, I. Smirnov, T. Murashko [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 330 | _a4-O-Я-D-(glucopyranosyloxy)-benzoic acid sodium salt (4-GBA) is promising potassium-sparing diuretic and anti-inflammatory drug. For the survey of 4-GBA as pharmaceutical substance, a durable method of its quantification is needed. In the present study, a titrimetric method for 4-GBA quantification since it is evident, very simple, fast, applicable for routine analysis and there is no need of using reference standards was developed. Aqueous titration gave unsatisfactory result. Thus, based on the weak basic properties of the 4-GBA, non-aqueous titration was chosen. Glacial acetic acid was used as a solvent, and an anhydrous solution of perchloric acid in glacial acetic acid was used as a titrant. End-point detection was carried out potentiometrically (method A) and visually with violet crystalline as an indicator (method B). Using aqueous titration, we determined pKa of 4-GBA as 4.27. The developed non-aqueous titration method is of excellent linearity (r2 = 0.9995 and r2 = 0.9947 for method A and method B, respectively), accuracy (recovery from 98.8 to 101.1 % and from 98.1 to 103.2 % for method A and method B, respectively) and precision (RSD = 2% for intra- and inter-day analysis). The developed method is fast, simple, cheap and is applicable for the quantitative determination of 4-GBA both in pure form, bulk and pharmaceutical formulations. | ||
| 461 | _tMalaysian Journal of Analytical Sciences | ||
| 463 |
_tVol. 25, No. 1 _v[P. 95-104] _d2021 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aglucosides | |
| 610 | 1 | _apotassium-sparing diuretics | |
| 610 | 1 | _avalidation methods | |
| 610 | 1 | _anon-aqueous titration | |
| 610 | 1 | _aquantitative determination | |
| 701 | 1 |
_aIvanov _bA. A. _cspecialist in the field of Electrophysics _cengineer of Tomsk Polytechnic University _f1990- _gAleksey Alekseevich _2stltpush _3(RuTPU)RU\TPU\pers\35679 |
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| 701 | 1 |
_aSmirnov _bI. _gIvan |
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| 701 | 1 |
_aMurashko _bT. _gTatjyana |
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| 701 | 1 |
_aTrusova _bM. E. _corganic chemist _cAssociate professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1982- _gMarina Evgenievna _2stltpush _3(RuTPU)RU\TPU\pers\31823 |
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| 701 | 1 |
_aStepanova _bE. V. _cchemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences _f1988- _gElena Vladimirovna _2stltpush _3(RuTPU)RU\TPU\pers\34245 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20220411 _gRCR |
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| 856 | 4 | _uhttps://mjas.analis.com.my/mjas/v25_n1/pdf/Ivanov_25_1_9.pdf | |
| 942 | _cCF | ||