| 000 | 05862nlm1a2200601 4500 | ||
|---|---|---|---|
| 001 | 667939 | ||
| 005 | 20231030042132.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\39150 | ||
| 035 | _aRU\TPU\network\36621 | ||
| 090 | _a667939 | ||
| 100 | _a20220517a2021 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aFunctionalization of additive-manufactured Ti6Al4V scaffolds with poly(allylamine hydrochloride)/poly(styrene sulfonate) bilayer microcapsule system containing dexamethasone _fE. A. Chudinova, A. Koptyug, Yu. R. Mukhortova [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 89 tit.] | ||
| 330 | _aPorous titanium alloy Ti6Al4V scaffolds manufactured via electron beam melting (EBM®) reveal broad prospects for applications in bone tissue engineering. However, local inflammation and even implant failure may occur while placing an implant into the body. Thus, the application of drug carriers to the surface of a metallic implant can provide treatment at the inflammation site. In this study, we propose to use polyelectrolyte (PE) microcapsules formed by layer-by-layer (LbL) synthesis loaded with both porous calcium carbonate (CaCO3) microparticles and the anti-inflammatory drug dexamethasone (DEX) to functionalize implant surfaces and achieve controlled drug release. Scanning electron microscopy indicated that the CaCO3 microparticles coated with PE bilayers loaded with DEX had a spherical shape with a diameter of 2.3 ± 0.2 µm and that the entire scaffold surface was evenly coated with the microcapsules. UV spectroscopy showed that LbL synthesis allows the manufacturing of microcapsules with 40% DEX. According to high performance liquid chromatography (HPLC) analysis, 80% of the drug was released within 24 h from the capsules consisting of three bilayers of polystyrene sulfonate (PSS) and poly(allylamine)hydrochloride (PAH). The prepared scaffolds functionalized with CaCO3 microparticles loaded with DEX and coated with PE bilayers showed hydrophilic surface properties with a water contact angle below 5°. Mouse embryonic fibroblast cells were seeded on Ti6Al4V scaffolds with and without LbL surface modification. The surface modification with LbL PE microcapsules with CaCO3 core affected cell morphology in vitro. The results confirmed that DEX had no toxic effect and did not prevent cell adhesion and spreading, thus no cytotoxic effect was observed, which will be further studied in vivo. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tMaterials Chemistry and Physics | ||
| 463 |
_tVol. 273 _v[125099, 14 p.] _d2021 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aadditive manufacturing | |
| 610 | 1 | _aTi6Al4V scaffolds | |
| 610 | 1 | _asurface modification | |
| 610 | 1 | _acalcium carbonate | |
| 610 | 1 | _amicroparticles | |
| 610 | 1 | _adexamethasone | |
| 610 | 1 | _aмикрочастицы | |
| 610 | 1 | _aдобавки | |
| 610 | 1 | _aповерхности | |
| 701 | 1 |
_aChudinova _bE. A. _cphysicist _claboratory assistant of Tomsk Polytechnic University _f1993- _gEkaterina Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\34765 |
|
| 701 | 1 |
_aKoptyug _bA. _gAndrey |
|
| 701 | 1 |
_aMukhortova _bYu. R. _cChemical engineer _cEngineer of Tomsk Polytechnic University _f1976- _gYulia Ruslanovna _2stltpush _3(RuTPU)RU\TPU\pers\46606 |
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| 701 | 1 |
_aPryadko _bA. _cSpecialist in the field of nuclear technologies _cResearch Engineer of Tomsk Polytechnic University _f1995- _gArtyom _2stltpush _3(RuTPU)RU\TPU\pers\46948 |
|
| 701 | 1 |
_aVolkova _bA. P. _cphysicist _cengineer of Tomsk Polytechnic University _f1998- _gAnastasia Petrovna _2stltpush _3(RuTPU)RU\TPU\pers\47017 |
|
| 701 | 1 |
_aIvanov _bA. A. _cspecialist in the field of Electrophysics _cengineer of Tomsk Polytechnic University _f1990- _gAleksey Alekseevich _2stltpush _3(RuTPU)RU\TPU\pers\35679 |
|
| 701 | 1 |
_aPlotnikov _bE. V. _cchemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences _f1983- _gEvgeny Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\32469 |
|
| 701 | 1 |
_aKhan _bE. A. _cchemical engineer _cAssociate Scientist of Tomsk Polytechnic University _f1997- _gElena Alekseevna _2stltpush _3(RuTPU)RU\TPU\pers\47219 |
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| 701 | 1 |
_aEpple _bM. _gMatthias |
|
| 701 | 1 |
_aSokolova _bV. _gViktoriya |
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| 701 | 1 |
_aPrymak _bO. _gOleg |
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| 701 | 1 |
_aDouglas _bT. _gTimothy |
|
| 701 | 1 |
_aSurmenev _bR. A. _cphysicist _cAssociate Professor of Tomsk Polytechnic University, Senior researcher, Candidate of physical and mathematical sciences _f1982- _gRoman Anatolievich _2stltpush _3(RuTPU)RU\TPU\pers\31885 |
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| 701 | 1 |
_aSurmeneva _bM. A. _cspecialist in the field of material science _cengineer-researcher of Tomsk Polytechnic University, Associate Scientist _f1984- _gMaria Alexandrovna _2stltpush _3(RuTPU)RU\TPU\pers\31894 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _bНаучно-исследовательский центр "Физическое материаловедение и композитные материалы" _h8209 _2stltpush _3(RuTPU)RU\TPU\col\24957 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20220517 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.matchemphys.2021.125099 | |
| 942 | _cCF | ||