| 000 | 03779nlm1a2200505 4500 | ||
|---|---|---|---|
| 001 | 668225 | ||
| 005 | 20231030042141.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\39449 | ||
| 035 | _aRU\TPU\network\33755 | ||
| 090 | _a668225 | ||
| 100 | _a20220701a2022 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aInfluence of eight ABCB1 polymorphisms on antidepressant response in a prospective cohort of treatment-free Russian patients with moderate or severe depression: An explorative psychopharmacological study with naturalistic design _fL. M. Geers, T. Ochi, N. M. Vyalova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aBackground: Many antidepressants are substrates of P-glycoprotein, an efflux transporter in the blood-brain-barrier encoded by the ABCB1 gene. Genetic variations might influence the transport rate of antidepressants and hence their pharmacological effects. This study investigates the influence of eight polymorphisms in the ABCB1 gene on antidepressant treatment response. Method: 152 patients were included from psychiatric departments of the Mental Health Research Institute in Tomsk. The difference in Hamilton-Depression-Rating-Scale (HAMD-17)-scores between baseline and week two, week two and four, and baseline and week four was used to estimate timing of improvement of depression. Associations between the ABCB1 gene-polymorphisms and reduction in HAMD-17 score were assessed using independent t-test and multiple linear regression. Results: Tricyclic antidepressants were associated with a higher reduction of HAMD-17 score when compared to SSRIs. The SNP rs2235040 A-allele had a significant positive influence on the ΔHAMD-17(0→2W) score but a significant negative influence on the ΔHAMD-17(2→4W) score. The rs4148739 G-allele had a significant negative influence on the ΔHAMD-17(0→2W) score but a significant positive influence on the ΔHAMD-17(2→4W) score. The SNP rs2235015 T-allele is significant negatively related to the ΔHAMD-17(2→4W) score. Conclusion: ABCB1 Genetic variations appear to affect speed but not magnitude of antidepressant drug response. | ||
| 461 | _tHuman Psychopharmacology: Clinical and Experimental | ||
| 463 |
_tVol. 37, iss. 3 _v[e2826, 10 p.] _d2022 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aABCB1 gene | |
| 610 | 1 | _aantidepressants | |
| 610 | 1 | _aHamilton Depression Rating Scale | |
| 610 | 1 | _aP-glycoprotein | |
| 610 | 1 | _aгены | |
| 610 | 1 | _aантидепрессанты | |
| 701 | 1 |
_aGeers _bL. M. _gLisanne |
|
| 701 | 1 |
_aOchi _bT. _gTaichi |
|
| 701 | 1 |
_aVyalova _bN. M. _gNataljya Mikhaylovna |
|
| 701 | 1 |
_aLosenkov _bI. S. _cInnokenty Sergeevich |
|
| 701 | 1 |
_aPaderina _bD. Z. _gDiana |
|
| 701 | 1 |
_aPozhidaev _bI. V. _gIvan Vyacheslavovich |
|
| 701 | 1 |
_aSimutkin _bG. G. _gGerman Gennadjevich |
|
| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
|
| 701 | 1 |
_aWilffert _bB. _gBob |
|
| 701 | 1 |
_aTouw _bD. J. _gDaniël |
|
| 701 | 1 |
_aLoonen _bA. _gAnton |
|
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа неразрушающего контроля и безопасности _bОтделение контроля и диагностики _h7978 _2stltpush _3(RuTPU)RU\TPU\col\23584 |
| 801 | 2 |
_aRU _b63413507 _c20220701 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1002/hup.2826 | |
| 942 | _cCF | ||