| 000 | 03902nlm1a2200457 4500 | ||
|---|---|---|---|
| 001 | 668500 | ||
| 005 | 20231030042150.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\39727 | ||
| 035 | _aRU\TPU\network\39394 | ||
| 090 | _a668500 | ||
| 100 | _a20221219a2022 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aNL | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aElectrospun polycaprolactone scaffolds loaded with a 1,4-naphthoquinone derivative for anticancer therapy _fN. V. Danilenko, E. N. Bolbasov, A. I. Khlebnikov [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 9 tit.] | ||
| 330 | _aThe development of bioresorbable scaffolds with anticancer properties for use in tissue repair after surgical resection of tumors is important. Naphthoquinones with high anticancer activity are promising compounds for creating anticancer scaffolds. Thus, electrospun polycaprolactone (PCL) scaffolds embedded with different concentrations of 2-chloro-3-((4-hydroxyphenyl)amino)-1,4-naphthoquinonone (NQCP4) were fabricated without changing the technological parameters of scaffold formation. Loading NQCP4 into the spinning solution at concentrations of 10 to 50 ?g/mL did not cause changes in the structure, strength, or wettability of the scaffold. However, increasing NQCP4 concentrations in the spinning solution enhanced anticancer properties of the scaffolds in vitro. Thus, the use of NQCP4 makes it possible to obtain promising PCL scaffolds for tissue repair, which are in demand for surgical resection of malignant neoplasms, while still maintaining the technological advantages of “classical” electrospinning technology. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tMaterials Letters | ||
| 463 |
_tVol. 327 _v[133062, 4 p.] _d2022 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _a1,4-Naphthoquinone derivative | |
| 610 | 1 | _aelectrospun scaffold | |
| 610 | 1 | _apolycaprolactone | |
| 610 | 1 | _aanticancer | |
| 701 | 1 |
_aDanilenko _bN. V. _cchemical engineer _cResearch Engineer, Tomsk Polytechnic University _f1992- _gNadezhda Viktorovna _2stltpush _3(RuTPU)RU\TPU\pers\37547 |
|
| 701 | 1 |
_aBolbasov _bE. N. _cphysicist _cAssociate Scientist of Tomsk Polytechnic University, Candidate of Sciences _f1981- _gEvgeny Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\30857 |
|
| 701 | 1 |
_aKhlebnikov _bA. I. _cChemist _cProfessor of Tomsk Polytechnic University _f1963- _gAndrey Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\33927 |
|
| 701 | 1 |
_aSchepetkin (Shchepyotkin) _bI. A. _cdoctor-biophysicist _cleading researcher of Tomsk Polytechnic University, candidate of medical science _f1962- _gIgor Aleksandrovich _2stltpush _3(RuTPU)RU\TPU\pers\37358 |
|
| 701 | 1 |
_aTverdokhlebov _bS. I. _cphysicist _cAssociate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science _f1961- _gSergei Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\30855 |
|
| 701 | 1 |
_aQuinn _bM. T. _gMark |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа ядерных технологий _bНаучно-образовательный центр Б. П. Вейнберга _h7866 _2stltpush _3(RuTPU)RU\TPU\col\23561 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИнженерная школа новых производственных технологий _bНаучно-образовательный центр Н. М. Кижнера _h7872 _2stltpush _3(RuTPU)RU\TPU\col\23556 |
| 801 | 2 |
_aRU _b63413507 _c20221219 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.matlet.2022.133062 | |
| 942 | _cCF | ||