| 000 | 02883nlm1a2200397 4500 | ||
|---|---|---|---|
| 001 | 668611 | ||
| 005 | 20231030042154.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\39848 | ||
| 035 | _aRU\TPU\network\39466 | ||
| 090 | _a668611 | ||
| 100 | _a20230111a2022 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 182 | 0 | _ab | |
| 200 | 1 |
_aExploiting photoredox catalysis for carbohydrate modification through C–H and C–C bond activation _fA. Shatskiy, E. V. Stepanova, M. D. Karkas |
|
| 203 | _celectronic | ||
| 300 | _aTitle screen | ||
| 320 | _a[References: 222 tit.] | ||
| 330 | _aPhotoredox catalysis has recently emerged as a powerful synthetic platform for accessing complex chemical structures through non-traditional bond disconnection strategies that proceed through free-radical intermediates. Such synthetic strategies have been used for a range of organic transformations; however, in carbohydrate chemistry they have primarily been applied to the generation of oxocarbenium ion intermediates in the ubiquitous glycosylation reaction. In this Review, we present more intricate light-induced synthetic strategies to modify native carbohydrates through homolytic C–H and C–C bond cleavage. These strategies allow access to glycans and glycoconjugates with profoundly altered carbohydrate skeletons, which are challenging to obtain through conventional synthetic means. Carbohydrate derivatives with such structural motifs represent a broad class of natural products integral to numerous biochemical processes and can be found in active pharmaceutical substances. Here we present progress made in C–H and C–C bond activation of carbohydrates through photoredox catalysis, focusing on the operational mechanisms and the scope of the described methodologies. | ||
| 461 | _tNature Reviews Chemistry | ||
| 463 |
_tVol. 6, iss. 11 _v[P. 782–805] _d2022 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _acarbohydrates | |
| 610 | 1 | _ahomogeneous catalysis | |
| 610 | 1 | _aphotocatalysis | |
| 610 | 1 | _aуглеводы | |
| 610 | 1 | _aгомогенный катализ | |
| 610 | 1 | _aфотокатализ | |
| 700 | 1 |
_aShatskiy _bA. _gAndrey |
|
| 701 | 1 |
_aStepanova _bE. V. _cchemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences _f1988- _gElena Vladimirovna _2stltpush _3(RuTPU)RU\TPU\pers\34245 |
|
| 701 | 1 |
_aKarkas _bM. D. _gMarkus |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20230111 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1038/s41570-022-00422-5 | |
| 942 | _cCF | ||