| 000 | 04670nlm1a2200517 4500 | ||
|---|---|---|---|
| 001 | 668673 | ||
| 005 | 20231030042156.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\39910 | ||
| 035 | _aRU\TPU\network\39328 | ||
| 090 | _a668673 | ||
| 100 | _a20230117a2022 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aNL | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aAntifouling surface for biomedical devices: Modification of COC surface by quaternary ammonium moieties via diazonium chemistry _fK. A. Nikiforova, A. Gorbunova, E. V. Plotnikov [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 48 tit.] | ||
| 330 | _aPrefilled biomedical devices (PFD) are growing in the pharmaceutical market due to the ease of delivering a precise dose of protein drugs. As an appealing alternative to the fragile glass, cyclic olefin copolymer (COC) was suggested. However, in the case of COC, the stability of the drug may be negatively impacted by protein aggregation. To potentially improve the surface properties of COC for PFDs, we performed functionalization of COC with quaternary ammonium moieties (QAS) using the advantages of diazonium surface chemistry. The successful functionalization of COC using QAS-diazonium salts (QAS-DS) with different alkyl chain lengths (C4, C8, C9, C10, C12) was confirmed by Raman spectroscopy and XPS measurements. Optical and fluorescence measurements revealed the optimal length of the alkyl chain-COC-C4 for improved antibiofouling performance towards bovine serum albumin (BSA). Moreover, in contrast to glass, polypropylene (PP), and pristine COC, COC-C4 allows storing the insulin for at least 2 weeks without the changes in protein structure according to dynamic light scattering and TEM images. Additionally, diazonium functionalization allows for conserving the high permeability resistance, transparency, and mechanical stiffness. The improved stability of insulin in a COC-C4 container is explained by the formation of an additional hydration layer serving as a barrier to undesired interaction with biomolecules. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tApplied Surface Science | ||
| 463 |
_tVol. 603 _v[154415, 25 p.] _d2022 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _acyclic olefin copolymer | |
| 610 | 1 | _aquaternary ammonium salts | |
| 610 | 1 | _aprefilled biomedical devices | |
| 610 | 1 | _afunctionalization | |
| 610 | 1 | _aсополимеры | |
| 610 | 1 | _aциклические олефины | |
| 610 | 1 | _aчетвертичные соли | |
| 610 | 1 | _aаммониевые соли | |
| 610 | 1 | _aбиомедицинские устройства | |
| 610 | 1 | _aфункционализация | |
| 701 | 1 |
_aNikiforova _bK. A. _cChemical engineer _cEngineer of Tomsk Polytechnic University _f1988- _gKsenia Alekseevna _2stltpush _3(RuTPU)RU\TPU\pers\44186 |
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| 701 | 1 |
_aGorbunova _bA. _cchemical engineer _cengineer of Tomsk Polytechnic University _f1998- _gAlina _2stltpush _3(RuTPU)RU\TPU\pers\46791 |
|
| 701 | 1 |
_aPlotnikov _bE. V. _cchemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences _f1983- _gEvgeny Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\32469 |
|
| 701 | 1 |
_aPostnikov _bP. S. _corganic chemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1984- _gPavel Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\31287 |
|
| 701 | 1 |
_aGuselnikova _bO. A. _cchemist _cResearcher at Tomsk Polytechnic University, Candidate of Chemical Sciences _f1992- _gOlga Andreevna _2stltpush _3(RuTPU)RU\TPU\pers\34478 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _bМеждународная научно-исследовательская лаборатория "Невалентные взаимодействия в химии материалов" _h8903 _2stltpush _3(RuTPU)RU\TPU\col\27854 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет _bИсследовательская школа химических и биомедицинских технологий _c(2017- ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20230117 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1016/j.apsusc.2022.154415 | |
| 942 | _cCF | ||